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Journal of Research in Medical Sciences، جلد ۲۰، شماره ۱۰، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Efficacy of microencapsulated lactic acid bacteria in Helicobater pylori eradication therapy
چکیده انگلیسی مقاله Background: Probiotic delivery systems are widely used nutraceutical products for the supplementation of natural intestinal fl ora. These delivery systems vary greatly in the eff ectiveness to exert health benefi ts for a patient. This study focuses on providing probiotic living cells with a physical barrier against adverse environmental conditions. Materials and Methods: Microencapsulation of the selected lactic acid bacteria (LAB) using chitosan and alginate was performed. Physical examination of the formulated LAB microcapsules was observed using phase contrast inverted microscope and scanning electron microscope (SEM). Finally, the survival of icroencapsulated and noncapsulated bacteria was cheeked in the simulated human gastric tract (GT). The potential antimicrobial activity of the most potent microencapsulated LAB strain was in vivo evaluated in rabbit models. Results: Microencapsulated L. plantarum, L. acidophilus, and L. bulgaricus DSMZ 20080 were loaded with 1.03 × 1010 CFU viable bacteria/g, 1.9 × 1010 CFU viable bacteria/g, and 5.5 × 109 CFU viable bacteria/g, respectively. The survival of microencapsulated cells was significantly higher than that of the free cells after exposure to simulated gastric juice (SGJ) at pH 2. Additionally, in simulated small intestine juice (SSJ),larger amounts of the selected LAB cells were found, whereas in simulated colon juice (SCJ), the released LAB reached the maximum counts. In vivo results pointed out that an 8-week supplementation with a triple therapy of a microencapsulated L. plantarum,L. acidophilus, and L. bulgaricus DSMZ 20080 might be able to reduce H. pylori. Conclusion: Microencapsulated probiotics could possibly compete with and downregulate H. pylori infection in humans.
کلیدواژه‌های انگلیسی مقاله Helicobacter pylori (H. pylori), microcapsule, probiotics
نویسندگان مقاله a خلیل مها | a khalil maha


m el sheekh مصطفی | m el sheekh mostafa


i el adawi حالا | i el adawi hala


m el deeb nehal | m el deeb nehal


z حسین محمد | z hussein mohamed


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10338
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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