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Journal of Research in Medical Sciences، جلد ۲۰، شماره ۱۰، صفحات ۰-۰
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عنوان انگلیسی Effect of tetanus-diphtheria (Td) vaccine on immune response to hepatitis B vaccine in healthy individuals with insufficient immune response
چکیده انگلیسی مقاله Background: Hepatitis B virus (HBV) fails to produce appropriate immune responses in some healthy individuals; thus, different strategies have been adopted to promote immune responses. The current study aimed at evaluating the efficacy of HBV vaccine coadministered with tetanus-diphtheria (Td) vaccine compared with HBV vaccine in healthy individuals through measuring hepatitis B surface antibody (HBsAb) levels. Materials and Methods: This was a randomized controlled clinical trial, which was implemented in Isfahan, Isfahan Province (Iran) in 2013. One hundred and forty healthy individuals, whose HBsAb titers were less than 10 IU/L were recruited. The subjects were randomly assigned to either in intervention or control trials. Th e control group received 40 ?g of recombinant HBV vaccines intramuscularly injected at 0, 1, and 6 months; however, the intervention group was simultaneously vaccinated by Td with the first dose of HBV vaccine. HBV antibody levels (titer) were measured before the vaccination and 6 months after the last vaccination. Results: Antibody titers of the subjects in the intervention and control groups increased from 5.07 ± 2.9 IU/L to 744.45 ± 353.07 IU/L and from 4.45 ± 3.4 IU/L to 589.94 ± 353 IU/L, respectively (both P < 0.001). Also, the mean difference of antibody titer was signifi cantly diff erent between the two groups (P = 0.011). Conclusion: Td vaccination can be applied as a feasible approach to promote efficient and persistent immunity in healthy individuals with insuffi cient HBsAb titers.
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نویسندگان مقاله مریم صالحی | maryam salehi


عباس حقیقت | abbas haghighat


حسن صالحی | hassan salehi


رویا طالبان | roya taleban


مرضیه صالحی | marzieh salehi


نادر کلباسی | nader kalbasi


محمد معافی | mohammad moafi


محمد مهدی صالحی | mohammad mahdi salehi


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10339
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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