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Journal of Research in Medical Sciences، جلد ۲۰، شماره ۸، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی A phase II trial of neoadjuvant concurrent chemo-radioptherapy followed by resection for esophageal carcinoma
چکیده انگلیسی مقاله Background: Esophageal carcinoma is a common malignancy in the North East of Iran. Combined modality treatments have been adopted to improve survival in patients with esophageal carcinoma. In this trial, we evaluated the efficacy and toxicity of a preoperative concurrent chemoradiotherapy protocol in the patients with locally advanced esophageal carcinoma. Materials and Methods: Between 2006 and 2011, eligible patients with locally advanced esophageal carcinoma underwent concurrent radiotherapy and chemotherapy and 3-4 weeks later, esophagectomy. Pathologic response, overall survival rate, toxicity, and feasibility were evaluated. Results: One hundred ninety-seven patients with a median age of 59 (range: 27-70) entered the protocol. One hundred ninety-four cases (98.5%) had esophageal squamous cell carcinoma. Grades 3-4 of toxicity in patients undergoing neoadjuvant chemoradotherapy were as follows: Neutropenia in 21% and esophagitis in 2.5% of cases. There were 11 (5.6%) early death probably due to the treatment-related toxicities. One hundred twenty-seven patients underwent surgery with postsurgical mortality of 11%. In these cases, the complete pathological response was shown in 38 cases (29.9%) with a 5-year overall survival rates of 48.2% and median overall survival of 44 months (95% confidence interval, 24.46-63.54). Conclusion: The pathological response rate and the overall survival rate are promising in patients who completed the protocol as receiving at least one cycle of chemotherapy. However, the treatment toxicities were relatively high.
کلیدواژه‌های انگلیسی مقاله Esophageal carcinoma, neoadjuvant chemoradiation, survival
نویسندگان مقاله کاظم انوری | kazem anvari


سید امیر آل داوود | seyed amir aledavood


مهدی سیلانیان طوسی | mehdi seilanian toussi


فاطمه نصرتی | fatemeh nosrati


محمد ناصر فرقانی | mohammad naser forghani


سمیرا محتشمی | samira mohtashami


محمد تقی رجبی | mohammad taghi rajabi


غلامحسین نوفرستی | gholamhossein nowferesti


رهام سالک | roham salek


فاطمه همایی شاندیز | fatemeh homaee shandiz


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10290
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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