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Journal of Research in Medical Sciences، جلد ۲۰، شماره ۷، صفحات ۰-۰
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عنوان انگلیسی Serum anti-inflammatory cytokines for evaluation of inflammatory status in endometriosis
چکیده انگلیسی مقاله Background: Endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood, with an altered immunity as a possible key factor. The present study aimed to investigate the serum anti-inflammatory cytokine profile in the patients with endometriosis compared with the healthy controls. Materials and Methods: One hundred and sixty women were included, divided into two study groups (Group I — endometriosis; Group 2 — healthy women). We evaluated the serum levels of interleukin-1 receptor antagonist (IL-1Ra), IL-2, IL-2R, IL-4, IL-10, IL-13, and IL-15 with the use of Human multiplex cytokine panels. Statistical analyses (normality distribution analysis, independent t -test, Mann–Whitney U-test) were performed using IBM SPSS software (version 22.0) and GraphPad Prism (version 5.00); receiver operating characteristic curve were used to demonstrate the diagnostic performance of the studied markers. Results: The mean serum level of IL-1Ra, IL-4, and IL-10 were significantly higher in women with endometriosis compared to women free of disease from the control group (30.155, 138.459, and 1.489, respectively, compared to 14.109, 84.710, and 0.688, respectively; P < 0.001, P < 0.001, and P = 0.002, respectively.). No significant differences in the mean serum levels of IL-2, IL-13, and IL-15 were observed between the studied groups and IL-2R had a very low detection rate. Conclusion: Endometriosis is associated with elevated levels of anti-inflammatory cytokines, IL-1Ra, IL-4, and IL-10, markers that have a potential role as a prognostic factor for endometriosis.
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نویسندگان مقاله andrei mihai m lutan | andrei mihai m lutan


tudor drugan | tudor drugan


r zvan ciortea | r zvan ciortea


radu florin mocan hognogi | radu florin mocan hognogi


carmen bucuri | carmen bucuri


ماریا پاتریشیا رادا | maria patricia rada


دان mihu | dan mihu


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10274
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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