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Journal of Research in Medical Sciences، جلد ۲۰، شماره ۷، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Effect of supplements: probiotics and probiotic plus honey on blood cell counts and serum IgA in patients receiving pelvic radiotherapy
چکیده انگلیسی مقاله Background: Radiotherapy is frequently used in treatment approaches of pelvic malignancies. Nevertheless, it has some known systemic effects on blood cells and the immune system that possibly results in their susceptibility to infection. Probiotics are live microbial food ingredients that provide a health advantage to the consumer. Honey has prebiotic properties. The aim of this clinical trial was to investigate probable effects of probiotic or probiotics plus honey on blood cell counts and serum IgA levels in patients receiving pelvic radiotherapy. Materials and Methods: Sixty-seven adult patients with pelvic cancer were enrolled. Patients were randomized to receive either: (1) Probiotic capsules (including: Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus bulgaricus, Bifidobacterium breve, Bifidobacterium longum, and Streptococcus thermophiles ) ( n = 22), (2) probiotic capsules plus honey (n = 21) or (3) placebo capsules ( n = 24) all for 6 weeks. Blood and serum samples were collected for one week before radiotherapy and 24-72 h after the end of radiotherapy. Results: White blood cells (WBC), red blood cells (RBC), platelet counts, and serum IgA level were not significantly changed in patients taking probiotic (alone or plus honey) during pelvic radiotherapy. The mean decrease in RBC count was 0.52, 0.18, and 0.23 × 106 cells/?L, WBC count was 2.3, 1.21, and 1.34 × 103 cells/?L and platelet count was, 57.6, 53.3, and 66.35 × 103 cells/?L for the probiotic, probiotic plus honey, and placebo groups, respectively. The mean decrease of serum IgA was 22.53, 29.94, and 40.73 mg/dL for the probiotic, probiotic plus honey, and placebo groups, respectively. Conclusion: The observed nonsignificant effect of probiotics may be in favor of local effects of this product in the gut rather than systemic effects, however, as a trend toward a benefit was indicated, further studies are necessary in order to extract effects of probiotics or probiotic plus honey on hematologic and immunologic parameters in patients receiving pelvic radiotherapy.
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نویسندگان مقاله هاجر السادات منصوری تهرانی | hajar alsadat mansouri tehrani


محمد ربانی خوراسگانی | mohammad rabbani khorasgani


سید محسن حسینی | sayyed mohsen hosseini


فریبرز مکاریان | fariborz mokarian


هدی مهدوی | hoda mahdavi


مهناز رعایایی | mahnaz roayaei


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10276
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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