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Journal of Research in Medical Sciences، جلد ۲۰، شماره ۶، صفحات ۰-۰
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عنوان انگلیسی Factor V Leiden, factor V Cambridge, factor II GA20210 and MTFHR in cerebral venous and sinus thrombosis: A case-control study
چکیده انگلیسی مقاله Background: Factor V G1691A (FV Leiden), FII GA20210, and methylenetetrahydrofolate reductase (MTHFR) C677T mutations are the most common genetic risk factors for thromboembolism in the Western countries. However, there is rare data in Iran about cerebral venous and sinus thrombosis (CVST) patients. The aim of this study was to evaluate the frequency of common genetic thrombophilic factors in CVST patients. Materials and Methods: Forty consequently CVST patients from two University Hospital in Isfahan University of Medical Sciences aged more than 15 years from January 2009 to January 2011 were recruited.In parallel, 51 healthy subjects with the same age and race from similar population selected as controls. FV Leiden, FII GA20210,MTHFR C677T, and FV Cambridge gene mutations by polymerase chain reaction technique were evaluated in case and control groups. Results: FV Leiden, FII GA20210, and FV Cambridge gene mutations had very low prevalence in both case (5%, 2%, 0%) and control (2.5%, 0%, 0%) and were not found any signifi cant difference between groups. MTHFR C677T mutations was in 22 (55%) of patients in case group and 18 (35.5%) of control group (P = 0.09). Conclusion: This study showed that the prevalence of FV Leiden, FII GA20210, and FV Cambridge were low. Laboratory investigations of these mutations as a routine test for all patients with CVST may not be cost benefit.
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نویسندگان مقاله محمد سعادت نیا | mohammad saadatnia


منصور صالحی | mansour salehi


احمد موحدیان | ahmad movahedian


sz صمصام شریعت | sz samsam shariat


مهری سالاری | mehri salari


مرضیه تاجمیرریاحی | marzieh tajmirriahi


الهام asadimobarakeh | elham asadimobarakeh


رسول صالحی | rasoul salehi


گیلدا امینی | gilda amini


هما ابراهیمی | homa ebrahimi


احسان خردمند | ehsan kheradmand


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10238
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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