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Journal of Research in Medical Sciences، جلد ۲۰، شماره ۶، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Efficacy of Duloxetine add on in treatment of IBD patients: A Double-blind Controlled Study
چکیده انگلیسی مقاله Background: Treating inflammatory bowel disease (IBD) with antidepressants might be of utility to improve patient’s condition. The aim of this study was to assess the efficacy of Duloxetine on depression, anxiety, severity of symptoms, and quality of life (QOL) in IBD patients. Materials and Methods: In a randomized, double-blind, controlled clinical trial on 2013-2014, in Alzahra Hospital (Isfahan, Iran), 44 IBD patients were chosen to receive either duloxetine (60 mg/day) or placebo. They were treated in a 12 weeks program, and all of the participants also received mesalazine, 2-4 g daily. We assessed anxiety and depression with Hospital Anxiety and Depression Scale, the severity of symptoms with Lichtiger Colitis Activity Index and QOL with World Health Organization Quality of Life Instruments, before and just after the treatment. The data were analyzed using Paired sample t -test and ANCOVA. Results: In 35 subjects who completed the study, the mean (standard error [SE]) scores of depression and anxiety were reduced in duloxetine more than placebo group, significantly ( P = 0.041 and P = 0.049, respectively). The mean (SE) scores of severity of symptom were also reduced in duloxetine more than the placebo group, significantly ( P = 0.02). The mean (SE) scores of physical, psychological, and social dimensions of QOL were increased after treatment with duloxetine more than placebo group, significantly ( P = 0.001, P = 0.038, and P = 0.015, respectively). The environmental QOL was not increased significantly ( P = 0.260). Conclusion: Duloxetine is probably effective and safe for reducing depression, anxiety and severity of physical symptoms. It also could increase physical, psychological, and social QOL in patients.
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نویسندگان مقاله حامد دقاق زاده | hamed daghaghzadeh


فاطمه ناجی | fateme naji


حمید افشار | hamid afshar


محمد رضا شعربافچی | mohammad reza sharbafchi


آوات فیضی | awat feizi


محسن معروفی | mohsen maroufi


مهشید tabatabaeeyan | mahshid tabatabaeeyan


پیمان ادیبی | peyman adibi


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10244
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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