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Journal of Research in Medical Sciences، جلد ۲۰، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی Effects of vitamin D on retinal nerve fiber layer in vitamin D deficient patients with opticneuritis: Preliminary findings of a randomized, placebo-controlled trial
چکیده انگلیسی مقاله Background: There is accumulating evidence for a possible protective role of vitamin D in the development and disease course of multiple sclerosis. Whether vitamin D is also effective in treating patients with optic neuritis (ON) is not known. The aim of this study was to evaluate the effect of oral vitamin D on the thickness of retinal nerve fiber layer (RNFL) in vitamin D deficient patients with ON by optical coherence tomography. Materials and Methods: A Phase II placebo-controlled randomized clinical trial conducted between July 2011 and November 2012 included 52 patients with confirmed unilateral ON aged 15-38 years and low serum 25-hydroxyvitamin D levels. The main outcome measures were changes in thickness of RNFL and macula 6 months after treatment. Patients were randomly allocated to receive 6 months of treatment with adding either 50,000 IU/week vitamin D or placebo. Results: In the 27 patients treated with vitamin D, the mean (standard deviation [SD]) thickness of RNFL decreased from 111.3 (18.9) ?m at baseline to 91.4 (13.3) at the end of study period ( P < 0.001). Correspondingly, in the 25 patients treated with placebo, the mean (SD) thickness of RNFL decreased from 113.7 (21.5) ?m at baseline to 96.1 (12.3)at the end of study period ( P < 0.01). In both groups, the mean thickness of the macula did not change ( P > 0.05). Average thickness of RNFL at the end of trial did not differ between groups. Conclusion: Adding vitamin D to routine disease therapy had no significant effect on the thickness of RNFL or macula in patients with ON. This trial is registered on www.clinicaltrials .gov (ID NCT01465893).
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نویسندگان مقاله مهری سالاری | mehri salari


محسن جانقربانی | mohsen janghorbani


مسعود اعتمادی فر | masoud etemadifar


علیرضا دهقانی | alireza dehghani


حسن رزمجو | hassan razmjoo


غلامعلی نادریان | gholamali naderian


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10207
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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