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Journal of Research in Medical Sciences، جلد ۱۹، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی Serum levels of IL-17, IL-4, and INFγ in Serbian patients with early rheumatoid arthritis
چکیده انگلیسی مقاله Background: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease with autoimmune etiology, characterized by synovial inflammation and destruction of joint cartilage and bone. There are controversial data about the profile of interleukin-17 (IL-17A), interleukin-4 (IL-4), and interferon-gamma (INFγ), indicating in some studies the key role of IL-17, while in others the Th1 cytokines. Materials and Methods: Serum samples of 31 early RA patients were evaluated for erythrocytes sedimentation rate (ESR), rheumatoid factor (RF), C-reactive protein (CRP), anti-cyclic citrullinated peptide antibodies (anti-CCP), and for the tested cytokines (IL-17A, IL-4, and INFγ). Disease activity score (DAS28) calculation was done for all patients. Control serum samples were obtained from 29 healthy volunteers. Results: The levels of tested cytokines were significantly higher (IL-17A, p < 0.001; INFγ, p < 0.001; IL-4, p < 0.01) in patients with early RA, compared to the healthy controls. In early RA patients, a strong correlation of serum IL-17A was found with DAS28, ESR, and CRP. Also, significant negative correlation was found between serum INFγ levels and the DAS28 score, indicating that INFγ may play a key role in maintaining immune homeostasis in patients with RA. Conclusion: The mean serum IL-17A levels in patients with early RA, corresponded with the disease activity and severity. This might highlight the usefulness of the serum IL-17A level in defining the activity and predictive patterns, for aggressive disease therapy, and it might express specific therapeutically targets.
کلیدواژه‌های انگلیسی مقاله Early rheumatoid arthritis, IL-17A, IL-4, INFγ
نویسندگان مقاله voja pavlovic | voja pavlovic


aleksandar dimic | aleksandar dimic


جهانگیر milenkovic | sasa milenkovic


دانه krtinic | dane krtinic


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9821
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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