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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۷، صفحات ۶۰۰-۰
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عنوان انگلیسی Pharmacokinetic drug‑drug interaction and their implication in clinical management
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Drug‑drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly‑therapy, with a prevalence of 20‑40%. In particular, poly‑therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications.
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نویسندگان مقاله palleria caterina | palleria caterina
department of health science, school of medicine, university of catanzaro, rete regionale di informazione sul farmaco, ao materdomini catanzaro, italy


di paolo antonello | di paolo antonello
department of clinical and experimental medicine, division of pharmacology, university of pisa, italy


giofr㨠chiara | giofr㨠chiara
department of health science, school of medicine, university of catanzaro, rete regionale di informazione sul farmaco, ao materdomini catanzaro, italy


caglioti chiara | caglioti chiara
department of health science, school of medicine, university of catanzaro, rete regionale di informazione sul farmaco, ao materdomini catanzaro, italy


leuzzi giacomo | leuzzi giacomo
azienda sanitaria provinciale catanzaro, department of primary care, italy


siniscalchi آنتونیو | siniscalchi antonio
department of neurology, cosenza hospital, italy


de sarro giovambattista | de sarro giovambattista
department of health science, school of medicine, university of catanzaro, rete regionale di informazione sul farmaco, ao materdomini catanzaro, italy


gallelli luca | gallelli luca
department of health science, school of medicine, university of catanzaro, rete regionale di informazione sul farmaco, ao materdomini catanzaro, italy
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9310
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Articles
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