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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۶، صفحات ۴۷۳-۰
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عنوان انگلیسی The association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal reflux
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: The association of gastro-esophageal reflux (GER) with a wide variety of pulmonary disorders was recognized. We aimed to evaluate the effect of GER-induced esophagitis on airway hyper-reactivity (AHR) in patients and the response to treatment. Materials and Methods: In this cohort study, 30 patients attending the gastrointestinal clinic of a university hospital with acid reflux symptoms were included. All patients were evaluated endoscopically and divided into case group with esophagitis and control group without any evidence of esophagitis. Spirometry and methacholine test were done in all patients before and after treatment of GER with pantoprazole 40 mg daily for six months. Results: There was a significant difference in the rate of positive methacholine test between the cases (40%) and the controls (6.7%) prior to anti-acid therapy ( P < 0.0001). After six months of treatment, the frequency of positive methacholine test diminished from 40 to 13.3% in the case group ( P value < 0.05) but did not change in the controls ( P =0.15). Conclusion: The presence of esophagitis due to GER would increase the AHR and treatment with pantoperazole would decrease AHR in patients with proved esophagitis and no previous history of asthma after six months.
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نویسندگان مقاله اشرف کرباسی | ashraf karbasi
baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

محمد امامی اردستانی | mohammad emami ardestani
chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

مصطفی قانعی | mostafa ghanei
chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

علی امینی هرندی | ali amini harandi
department of neurology, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9277
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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