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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۶، صفحات ۴۸۷-۰
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عنوان انگلیسی Methylenetetrahydrofolate reductase C677T mutation and risk of retinal vein thrombosis
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: Elevated plasma homocysteine (Hcy) level has been established as a significant risk factor for venous thrombosis and cardiovascular disease . Homozygosity for the methylenetetrahydrofolate reductase (MTHFR) C677T mutation has been associated with elevated plasma Hcy concentration and may contribute to retinal vein thrombosis (RVT) development. The aim of the present study was to investigate whether the hyperhomocysteinemia and/or homozygosity for the MTHFR C677T mutation are associated with an increased risk for RVT. Materials and Methods: Our study population consisted of 73 consecutive patients (50-78 years old ) with RVT and 73 control subjects (51 -80 years old) , matched for age and sex. Genotyping for the MTHFR C677T mutation was performed by polymerase chain reaction-restriction fragment length polymorphism technique and Hcy level was determined by an enzyme immunoassay kit. Results: T he prevalence of 677TT genotype was higher in patients than control subjects, but the difference in frequency didn’t reach a significant value ( P = 0.07). The frequency of the 677T allele was 26% and 21.2% in patients and controls, respectively and did not differ significantly between the two groups (odds ratio = 1.3, 95% confidence interval ( 0.75-2.24), P = 0.33). Fasting plasma total Hcy level was significantly higher in patients than controls ( P = 0.001). Conclusion: Our study demonstrated that hyperhomocysteinemia, but not the MTHFR C677T mutation, is associated with RVT.
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نویسندگان مقاله محمد سلیمان سلطانپور | mohammad soleiman soltanpour
department of laboratory sciences, school of paramedical amp;amp; health, zanjan university of medical sciences, zanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

زهرا سهیلی | zahra soheili
1department of molecular genetics, national research centre for genetic engineering and biotechnology, tehran, iran


علی شاکری زاده | ali shakerizadeh
department of medical physics, faculty of medical sciences, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

علی اکبر پورفتح اله | ali akbar pourfathollah
department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

شهرام سمیعی | shahram samiei
department of biochemistry, iranian blood transfusion organization, tehran, iran

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

رضا مشکانی | reza meshkani
department of biochemistry, faculty of medical sciences, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد شاه جهانی | mohammad shahjahani
department of hematology, faculty of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

عباس کریمی | abbas karimi
department of molecular medicine, school of advanced medical technologies, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9280
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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