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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۵، صفحات ۳۷۰-۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: Cisplatin (cis-diamminedichloroplatinum II; CP) is used widely as an antitumor drug in clinics, but is accompanied with renal toxicity. Cisplatin induced nephrotoxicity consists of change in kidney weight, histological changes in kidney and increase in serum creatinine (Cr) and blood urea nitrogen (BUN). This study was designed to find out a model for prediction of cisplatin induced nephrotoxicity. Materials and Methods: Pathological damage score, kidney weight, BUN, and Cr of 227 rats that were involved in different projects were determined. A total of 187 rats were treated with 7 mg/kg cisplatin and sacrificed 1 week later. Results: There was a good significant correlation between normalized kidney weight and logarithmic scale of BUN and Cr. Relationship between BUN, Cr or normalized kidney weight and pathology damage score was significant. Conclusion: Normalized kidney weight and pathology damage score is a good predictor of renal function in cisplatin induced nephrotoxicity in experimental rats.
کلیدواژه‌های انگلیسی مقاله Cisplatin, kidney weight, nephrotoxicity, pathology, rat
نویسندگان مقاله مهدی نعمت بخش | mehdi nematbakhsh
department of physiology, kidney diseases research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فرزانه اشرفی | farzaneh ashrafi
department of hematology oncology, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

حمید نصری | hamid nasri
kidney diseases research center, department of hematology oncology, departments of internal medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

اردشیر طالبی | ardeshir talebi
department of clinical pathology, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

زهرا پزشکی | zahra pezeshki
water and electrolytes research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فاطمه اشراقی | fatemeh eshraghi
water and electrolytes research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مریم حقیقی | maryam haghighi
water and electrolytes research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9204
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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