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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۵، صفحات ۳۷۴-۰
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عنوان انگلیسی Whether vitamin D3 is effective in reducing proteinuria in type 2 diabetic patients?
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: Nowadays Vitamin D deficiency is a notable medical condition world-wide and also in Iran. Since, vitamin D can have reoprotective effect by inhibiting the renin-angiotensin system; it appears that low vitamin D level can worsen the renal injury in diabetic patients. This study demonstrates the effect of vitamin D 3 therapy on reducing proteinuria in diabetic patients with concomitant diabetic nephropathy and vitamin D deficiency after controlling hypertension and use of angiotensin converting enzyme inhibitors (ACEIs) or angiotensin II type receptor blockers (ARBs). Materials and Methods: In this randomized double blinded parallel groups clinical trial, 51 diabetic patients with proven nephropathy and vitamin D deficiency/insufficiency and stable hypertension,dyslipidemia, and hyperglycemic treatment were enrolled. Th e patients were divided randomly into two groups (treatment and placebo group). Patients received oral vitamin D 3 (pearl 50000 IU) or placebo one pearl every week for 12 weeks. Patients were assessed at baseline and 12 weeks after intervention from the point of 25(OH) D level, and urine albumin/creatinine ration (UACR). Results: Mean serum 25(OH) D concentrations were 14.06 ng/ml and 16.05 ng/ml before treatment. Furthermore, after intervention, its levels were risen to71.23 and 17.63 in drug and placebo groups, respectively. Whereas, UACR as the main variable did not change significantly after intervention in both groups ( P = 0.919). Conclusion: According to our finding, there was not a decrease in proteinuria in diabetic patients who received vitamin D for a period of 3 months.
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نویسندگان مقاله نوشین احمدی | nooshin ahmadi
resident of internal medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مژگان مرتضوی | mojgan mortazavi
department of nephrology, isfahan kidney diseases research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

بیژن ایرج | bijan iraj
department of clinical nutrition, isfahan endocrine and metabolism research center, isfahan, iran


غلامرضا عسکری | gholamreza askari
assistant professor of endocrinology, isfahan endocrine and metabolism research center, isfahan, iran
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9205
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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