این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Research in Medical Sciences، جلد ۱۸، شماره ۵، صفحات ۴۲۷-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی lysine, proline, epigallocatechin gallate, zinc and alpha-1-antitrypsin on lung carcinogenesis induced by benzo(a) pyrene in mice
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: This study was aimed to evaluate protective and therapeutic effects of a specific mixture, containing vitamin C, lysine, proline, epigallocatechin gallate and zinc, as well as alpha-1-antitrypsin protein on lung tumorigenesis induced by benzo(a) pyrene (B (a) P) in mice. Materials and Methods: Swiss albino mice were divided into two main experiments, experiment (1) the mice were injected with 100 mg/kg b (a) P and lasted for 28 weeks, while experiment (2) the mice were injected with 8 doses each of 50 mg/kg b (a) P and lasted for 16 weeks. Each experiment divided into fi ve groups, group (I) received vehicle, group (II) received the protector mixture, group (III) received the carcinogen, group (IV) received the protector together with the carcinogen (simultaneously) and group (V) received the carcinogen then the protector (consecutively). Results: Total sialic acid, thiobarbituric acid reactive substances, vascular epithelial growth factor, hydroxyproline levels, as well as elastase and gelatinase activities showed significant elevation in group (III) in the two experiments comparing to control group ( P < 0.001). These biochemical alterations were associated with histopathological changes. Administration of the protector in group IV and group V causes significant decrease in such parameters when compared with group III in the two experiments ( P < 0.001). Conclusion: Th e present protector mixture has the ability to suppress neoplastic alteration and restore the biochemical and histopathological parameters towards normal on lung carcinogenesis induced by benzo(a) pyrene in mice. Furthermore, the present mixture have more protective rather than therapeutic action.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله احمد محمد ابراهیم | ahmed mohamed ibrahim
department of biochemistry, national research centre, cairo, egypt


ابراهیم حسن borai | ibrahim hassan borai
biochemistry, faculty of science, ain shams university, cairo, egypt


ممدوح moawad علی | mamdouh moawad ali
department of biochemistry, national research centre, cairo, egypt


حالا مصطفی ghanem | hala mostafa ghanem
biochemistry, faculty of science, ain shams university, cairo, egypt


azza el سید احمد حجازی | azza el sayed ahmed hegazi
department of pathology, national hepatology and tropical medicine research institute, cairo, egypt


amria ممدوح موسی | amria mamdouh mousa
department of biochemistry, national research centre, cairo, egypt
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9223
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات