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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Association between serum biochemical levels, related to bone metabolism and Parkinson’s disease
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: Vitamin D insufficiency and serum calcium disturbance have been reported to be more common in Parkinson’s disease (PD) patients than in healthy control subjects, which may be due to a chronic disease or reduced mobility contributes to these relatively disturbances. Because of the high-vitamin D insufficiency in our population, we aimed to compare a biochemical levels which are related to bone metabolism, in PD patients in comparison with age-matched healthy controls, for the 1 st time in a Middle East population. Materials and Methods: This case-control study was involved 105 (20 were excluded) PD patients, who were age- and -sex matched with 112 controls. 25-hydroxyvitamin D ( 25OHD) and parathyroid hormone analyzed by enzyme immunoassay; another laboratory data including, calcium, phosphorous, and alkaline phosphatase were performed by spectrophotometric methods. Results: There was no significant difference in 25OHD between PD patients and control group ( P = 0.071). 25OHD level was not significantly different in PD patients compared to controls {odds ratio 1.003, ( c onfidence interval [CI], 0.98-1.02), P value 0.793}. None of the other biochemical levels did not induce more chance for PD, only we observed in men has more risk of PD than women (odds ratio 2.53, [CI, 1.27-5.03], P value 0.008). Conclusion: Our data do not support a possible role of vitamin D insufficiency in PD. Regarding to variable changes in biochemical markers in PD patients than in controls; further studies are suggested to determine any plausibility role of them as a causal relationship or as an outcome of PD.
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نویسندگان مقاله رخساره معمار | rokhsareh meamar
isfahan neurosciences research center, isfahan university of medical sciences and department of medical science, najafabad branch, islamic azad university, najafabad branch, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد مراثی | mohammad maracy
department of biostatistics and epidemiology, school of public health, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

احمد چیت ساز | ahmad chitsaz
isfahan neurosciences research center and department of neurology, medical school, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد رضا آقای قزوینی | mohammad reza aghaye ghazvini
isfahan center of health research, national institute of health research, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مریم ایزدی | maryam izadi
young researchers club, najafabad branch, islamic azad university, najafabad branch, isfahan, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

امیر پویا تنهایی | amir pouya tanhaei
isfahan neurosciences research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9029
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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