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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۲، صفحات ۱۰۷-۰
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عنوان انگلیسی Comparison of sedation effectiveness of remifentanil-dexmedetomidine and remifentanil-midazolam combinations and their effects on postoperative cognitive functions in cystoscopies: A randomized clinical trial
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: T he aim of the study is to compare the effects of remifentanil/dexmedetomidine and remifentanil/midazolam combinations in monitored anesthesia care (MAC) during cystoscopies. Materials and Methods: F orty patients who received remifentanil infusion of 0.05 m g kg -1 min -1 for cytoscopy procedure were randomized into two groups: E ither dexmedetomidine 1 m g kg -1 (Group D) or midazolam 0.2 mg kg -1 h -1 (Group M) was administered intravenously for the first 10 min. Subsequently, anesthesia was maintained by using the bispectral index as a continuous infusion of dexmedetomidine (0.2-0.7 m g kg -1 h -1 ) or midazolam (0.05-0.15 mg kg -1 h -1 ). Heart rate, mean arterial pressure, mini-mental state examination findings, levels of sedation andanalgesia, and the patient’s and surgeon’s satisfaction were recorded. Results: S uccessful sedation and analgesia were achieved in all the patients. We were able to reach the target sedation level faster in Group D ( P < 0.0001). In Group D, the cognitive functions were less affected than in Group M ( P < 0.0001). Patient’s and surgeon’s satisfaction were significantly higher in Group D. Conclusion: T he targeted sedation levels were achieved in a shorter period with dexmedetomidine-remifentanil compared to midazolam-remifentanil. The dexmedetomidine-remifentanil combination was observed to affect the cognitive functions less than midazolam-remifentanil did with shorter recovery times. Besides, patient’s and surgeon’s satisfaction rates were superior with dexmedetomidine-remifentanil. It was concluded that dexmedetomidine-remifentanil may be a combination of choice for monitored anesthesia care applications in outpatient surgical procedures of short duration.
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نویسندگان مقاله آیسه hande arpacä± | ayse hande arpacä±
department of oral and maxillofacial, faculty of dentistry, ankara university and gazi university faculty of medicine, ankara, turkey


fusun bozkä±rlä± | fusun bozkä±rlä±
department of anaesthesiology and reanimation,2 gazi university faculty of medicine, ankara, turkey
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8956
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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