این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Research in Medical Sciences، جلد ۱۸، شماره ۲، صفحات ۱۲۳-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: Taste abnormalities are common among cancer patients after starting radiotherapy or chemotherapy. Considering the role of zinc and reports on its beneficial effects in taste perception, we evaluated the preventive effects of zinc sulfate on radiation-induced taste alterations. Materials and Methods: In a randomized, placebo-controlled trial, adult patients with head and neck cancers who were on schedule for radiotherapy, with or without chemotherapy, were allocated to receive zinc sulfate (50 mg, three times a day) or placebo; started with beginning of radiotherapy and continued for one month later. Taste acuity was determined by measuring detection and recognition thresholds for four taste qualities at baseline, at the end of radiotherapy, and a month later using the Henkin method. Results: Thirty-five patients (mean age = 59.2 ± 16.5, 60% male) completed the trial. The two groups were similar at baseline. After radiotherapy, and one month later, there was a significant increase in taste perception threshold for bitter, salty, sweet, and sour tastes in the placebo group ( P = 0.001). In those who received zinc, there was only slight increase in threshold for perception of the salty taste ( P = 0.046). No relevant side effects due to zinc sulfate were reported. Conclusion: Zinc supplementation in head/neck cancer patients under radiotherapy can prevent radiation-induced taste alterations. Further studies with longer follow-ups and with different doses of zinc supplementation are warranted in this regard.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله نادیا نجفی زاده | nadia najafizade
departments of radiation-oncology, school of medicine, isfahan university of medical science, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

سیمین همتی | simin hemati
departments of radiation-oncology, school of medicine, isfahan university of medical science, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

عباس gookizade | abbas gookizade
departments of radiation-oncology, school of medicine, isfahan university of medical science, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

نظام الدین برجیس | nezameddin berjis
departments of head and neck surgery, school of medicine, isfahan university of medical science, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

مصطفی هاشمی | mostafa hashemi
departments of head and neck surgery, school of medicine, isfahan university of medical science, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

سهیل وجدانی | soheil vejdani
departments of radiation-oncology, school of medicine, isfahan university of medical science, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

علیرضا قنادی | alireza ghannadi
department of pharmacognosy, school of pharmacy, isfahan university of medical science, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

آرمین دخت shahsanaee | armindokht shahsanaee
departments of community medicine, school of medicine, isfahan university of medical science, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

نفیسه ارباب | nafise arbab
departments of radiation-oncology, school of medicine, isfahan university of medical science, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8959
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات