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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۱، صفحات ۴۷-۰
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عنوان انگلیسی The effects of oral vitamin D on insulin resistance in pre-diabetic patients
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: Some epidemiological and interventional studies have shown the role of vitamin D on insulin secretion and resistance. A previous study in our center showed that intramuscular vitamin D decreases insulin sensitivity in pre-diabetic patients. We investigated the role of oral vitamin D on the insulin sensitivity index and insulin resistance in pre-diabetic patients. Methods: In a randomized clinical trial, we divided 45 people with pre-diabetes aged 47.4 ± 6.6 (range 33–61) years into three groups: group A subjects treated with 50,000 IU oral vitamin D and 500 mg calcium carbonate ( n = 21), group B subjects treated with a single 300,000 IU intramuscular vitamin D and 500 mg calcium carbonate ( n = 9), and group C subjects treated with 500 mg calcium carbonate alone ( n = 15). Serum 25-hydroxyvitamin D [25(OH)D] was measured at baseline. If it was less than 75 nmol/l, 50,000 IU vitamin D was given weekly, and if serum 25(OH)D was more than that, vitamin D was administered every 2 weeks. Before and after 12 weeks of treatment, a 75-g glucose tolerance test was performed. We used paired t -test and analysis of variance (ANOVA) to analyze the data. P values less than 0.05 were considered significant. Results: Mean (SD) of serum vitamin D increased from 77.5 ± 39.2 to 118.8 ± 56.3 nmol/l ( P = 0.009) in group A and from 80 ± 36 to 102.8 ± 43.3 nmol/l ( P = 0.053) in group B, and decreased from 44.8 ± 18.3 to 34.6 ± 13.9 nmol/l ( P = 0.06) in group C. Insulin sensitivity index (Matsuda) decreased from 11.4 ± 3 to 9.9 ± 3.2 ( P = 0.046) in group A, but in comparison with other groups, it was not significant. Conclusion: Oral vitamin D had no effect on insulin sensitivity in pre-diabetes patients in 12 weeks treatment. A randomized double-blind study with a longer duration of treatment is suggested to investigate the effect of vitamin D on insulin resistance.
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نویسندگان مقاله سید a حسینی | seyed a hoseini
department of internal medicine and endocrinology, isfahan endocrine and metabolism research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

اشرف امین الرعایا | ashraf aminorroaya
department of internal medicine and endocrinology, isfahan endocrine and metabolism research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

بیژن ایرج | bijan iraj
department of internal medicine and endocrinology, isfahan endocrine and metabolism research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مسعود امینی | massoud amini
department of internal medicine and endocrinology, isfahan endocrine and metabolism research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8896
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