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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۱۲، صفحات ۰-۰
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عنوان انگلیسی Aqueous concentrations of VEGF and soluble VEGF receptor-1 in diabetic retinopathy patients
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Background: The aim of this study was to simultaneously measure the concentrations of vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sVEGFR-1, also known as sFlt-1) in the aqueous humor of patients with non-proliferative diabetic retinopathy (NPDR) and to investigate whether aqueous levels of vascular endothelial growth factor (VEGF) and VEGFR-1 are related to diabetic macular edema. Materials and Methods: Aqueous humor was collected from 27 diabetic patients and 33 age- and sex-matched normoglycemic controls and analyzed for pro-angiogenic VEGF and angiogenic inhibitor VEGFR-1 by enzyme-linked immunosorbent assay (ELISA) . The mean foveal thickness was measured by optical coherence tomography (OCT). Results: There was no significant difference in the aqueous levels of VEGF in patients with NPDR compared with control subjects ( P > 0.05), while the NPDR patients had significantly lower sVEGFR-1 in their aqueous humor. Furthermore, a significant ( P < 0.01) positive correlation was observed between sVEGFR-1 concentration and the mean foveal thickness measured on OCT. Conclusion: The results suggest that decreased chelating effect of sVEGFR-1 may be the preliminary event allowing VEGF to activate the proangiogenic endothelial cell state and to induce permeability. The imbalance between angiogenic agent (VEGF) and the antiangiogenic factors (sFlt-1), which is disturbed in the diabetic state, may determine the fate of diabetic macular edema.
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نویسندگان مقاله شقایق حقجو جوانمرد | shaghayegh haghjooy javanmard
department of physiology, physiology research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

زهرا حسن پور | zahra hasanpour
department of physiology, physiology research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

زهرا عباسپور | zahra abbaspoor
department of physiology, physiology research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

غلام a نادریان | gholam a naderian
al zahra hospital, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مهدی جهانمرد | mehdi jahanmard
al zahra hospital, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8832
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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