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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۱۱، صفحات ۰-۰
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عنوان انگلیسی Associations between high density lipoprotein mean particle size and serum paraoxonase-1 activity
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA BACKGROUND: High density lipoprotein (HDL) particles are heterogeneous in composition, structure, size, and may differ in conferring protection against cardiovascular disease. HDL associated enzyme, paraoxonase-1 (PON1), has an important role in attenuation of atherogenic low density lipoprotein (LDL) oxidation. The aim of this study was to investigate the associations between HDL particle size and PON1 activity in relation to serum HDL cholesterol (HDL-C) levels. MATERIALS AND METHODS: One hundred and forty healthy subjects contributed to this study. HDL was separated by sequential ultracentrifugation and its size was estimated by dynamic light scattering. Paraoxonase activity was measured spectrophotometrically using paraoxon as substrate. RESULTS: Results of this study showed that PON1 activity had negative correlations with HDL mean particle size ( r = −0.22, P < 0.01), HDL 2 /HDL 3 ratio, and serum HDL-C levels ( r = −0 . 25, P < 0 . 01). HDL mean particle size and HDL 2 /HDL 3 ratio had negative correlation with body mass index (BMI), waist hip ratio (WHR), and serum triglyceride (TG) levels, and positive correlation with serum HDL-C levels. Serum HDL-C levels had significant positive correlations with age, total cholesterol (TC), and apolipoprotein A-I (apo A-I) and significant negative correlation with BMI, WHR, and TG. CONCLUSION: Based on the results of this study, determination of HDL mean particle size beside the serum PON1 activity may help to better understand the CAD risks, pathogenesis, and prognosis, and may also help to design therapeutic protocols toward beneficial modifications of HDL characteristics.
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نویسندگان مقاله امیر نادر امامی رضوی | amirnader emami razavi
department of clinical biochemistry, isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محسن آنی | mohsen ani
department of clinical biochemistry, isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مرتضی پورفرزام | morteza pourfarzam
department of clinical biochemistry, isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

غلام علی نادری | gholam ali naderi
isfahan cardiovascular research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8740
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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