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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۱۰، صفحات ۰-۰
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عنوان انگلیسی The effect of N-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity
چکیده انگلیسی مقاله Background : Peroxisome proliferator-activated receptor gamma (PPAR γ) is a transcription factor, which is abundantly expressed in adipose tissue and has a direct link to adiposity. It seems that long-chain polyunsaturated fatty acids (LC-PUFAs) can regulate PPAR γ expression. The purpose of this study was to investigate the effects of n-3LC PUFA supplementation on plasma levels of PPAR γ and thyroid hormones in obesity. Materials and Methods : In a randomized double-blind controlled trial, 66 subjects with obesity were assigned to 2 groups. Participants in intervention group consumed omega3 capsules contained 1000 mg n-3 fatty acids (180 mg of eicosapentaenoic acid [EPA] and 120 mg of docosahexaenoic acid [DHA]) and placebo group consumed placebo capsules contained paraffin twice a day for 4 wk. Fasting blood samples and weight measurements were collected at the baseline and at the end of the trial. Plasma PPAR γ and thyroid hormones were measured by ELISA. Data were analyzed using a repeated measure model-two factor for comparing two groups in two times. Result s: No significant changes were observed in PPAR γ levels between and within the groups after supplementation ( P >0.05). N-3LC PUFA supplementation significantly increased T4 levels after 4 wk ( P < 0.05) but T3 and TSH did not change significantly. Conclusion : Our study showed that n - 3LC PUFAs supplementation increased T4 levels. However, no significant changes in T3, TSH and PPAR γ plasma levels were observed in obese adults. Key words : Docosahexaenoic acid, eicosapentaenoic acid, N-3 LC PUFAs supplementation, obesity, peroxisome proliferator activated receptor gamma, thyrotropin, thyroxin, triiodothyronine Normal 0 false false false EN-US X-NONE AR-SA
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نویسندگان مقاله پریزاد ترقی جو | parizad taraghijou
students amp;amp; 039; research committee,department of nutrition, tabriz university of medical science, tabriz, iran

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

عبدالرسول صفاییان | abdolrasoul safaeiyan
departments of vital statistics and epidemiology, tabriz university of medical science, tabriz, iran

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

مجید مبصری | majid mobasseri
medicine, endocrinology and metabolism section, imam reza hospital , tabriz university of medical science, tabriz, iran

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

علیرضا استادرحیمی | alireza ostadrahimi
nutrition research center, tabriz university of medical science, tabriz, iran

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8706
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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