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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۱۰، صفحات ۰-۰
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عنوان انگلیسی Standard and pegylated interferon therapy of HDV infection: A systematic review and meta-analysis
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Background: Hepatitis D virus (HDV) infection is characterized by rapidly progressive liver disease with adverse prognosis in most patients. Although interferon is the only approved anti-HDV therapy, evidence regarding the efficacy and safety of its various regimens is either old or scattered. Materials and Methods: We searched systematically Medline, EMBASE, Scopus, the Cochrane Central Register of Controlled Trials, and ISI. The studies that evaluated treatment of chronic HDV infection with standard or pegylated interferon for at least 48 weeks were identified. Our inclusion criteria were positive anti-HDV antibody for 6 months and positive HDV-PCR at the start of study. We performed a meta-analysis for proportions using the arcsine transformation in random effects model. Sustained virological response (SVR) rate (negative Polymerase chain reaction (PCR) 6 months after cessation of therapy) was the end point of interest. Results: Data were abstracted from 14 studies containing 227 chronic HDV-infected patients who received standard or pegylated interferon alpha-2a or -2b. Twenty-one and 30 patients of 71 and 156 who received standard or peginterferon, respectively, beyond 48 weeks achieved SVR. Pooled SVR rates were 29% [95% confidence interval (CI) 19; 41] and 19% (95% CI 10; 29), respectively. The rates of treatment withdrawal were similar. Conclusion: Our systematic review indicates that the literature lacks sufficient evidence to establish precise recommendations for treatment of HDV infection. Meta-analysis of these studies shows that standard dose of peginterferon is more effective than high dose of standard interferon as anti-HDV therapy.
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نویسندگان مقاله سید موید علویان | seyed moayed alavian
baqiyatallah university of medical sciences, baqiyatallah research center for gastroenterology and liver disease, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

سید وحید طباطبایی | seyed vahid tabatabaei
university of muenster, st.-marien-hospital gmbh, klinik of gastroenterology, luenen, germany


بیتا بهنوا | bita behnava
baqiyatallah university of medical sciences, baqiyatallah research center for gastroenterology and liver disease, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

mario rizzetto | mario rizzetto
division of gastroenterology, molinette, university of turin, turin, italy
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8716
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Articles
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