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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۶، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی The role of VEGF in melanoma progressi
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Background: Melanoma is the most serious skin cancer. There is an established correlation between thickness and aggressiveness of the tumor. Nevertheless, the potential value of vascular endothelial growth factor (VEGF) in correlation with tumor progression remains unresolved. Materials and Methods: Thirty seven paraffin blocks of cutaneous melanoma were obtained from Pathology department of Al-zahra hospital between 2005 and 2010. The sections were stained with monoclonal mouse antibodies (mAbs) against vascular endothelial growth factor A and evaluated by distribution of expression of VEGF in tumor cells as 0, 0%; 1, 1%--25%; 2, 25%--50%; 3, >50% and the staining intensity from 0 (negative) to 3 (strong). The sum of intensity score and distribution score was then calculated as the VEGF index. The relationship between VEGF expression (distribution, intensity, and index) and tumor progression (vertical and radial growth, Clark’s level, and Breslow’s depth) was studied. SPSS software was used to analyze the data by ANOVA, and chi-square tests. Results: 51.4% of the patients showed vertical growth pattern. Mean Breslow’s depth was 1.84  } 1.79 mm. There was a significant association between growth pattern and VEGF distribution, intensity and index ( P = 0.006, P = 0.005, and P = 0.001 respectively). VEGF distribution, intensity, and index all had correlation with Breslow’s depth as well (ANOVA test: P = 0.003, P < 0.001, and P < 0.001 respectively) VEGF index had also correlation with Clark’s level, but this was not seen for VEGF distribution and intensity. Conclusion: VEGF expression (both VEGF distribution and intensity) is associated with progression of malignant melanoma. VEGF index can explain this association better.
کلیدواژه‌های انگلیسی مقاله Melanoma, vascular endothelial growth factor
نویسندگان مقاله پروین رجبی | parvin rajabi
department of pathology, isfahan university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

علی نشاط | ali neshat
department of pathology, isfahan university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مژگان مختاری | mozhgan mokhtari
department of pathology, isfahan university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد a رجبی | mohammad a rajabi
department of surgery, isfahan university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مهدی افتخاری | mehdi eftekhari
department of pathology, isfahan university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

پیام توکلی | payam tavakkoli
department of pathology, isfahan university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8487
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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