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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۵، صفحات ۰-۰
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عنوان انگلیسی Evaluation of in vitro sperm nuclear chromatin decondensation among different subgroups of infertile males in Mysore, India
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE FA BACKGROUND: Infertility is a condition associated with multiple etiologies. Sperm nuclear chromatin decondensation is one of the important events that occur during fertilization. Abnormal spermatogenesis leads to improper protamine package and chromatin condensation. The aim of the study was to analyze and understand the levels of fertilization capacity and nuclear stability of the spermatozoa in different infertile subgroups. METHODS: A total of 65 infertile males and 24 fertile males were employed in the study. Infertile subjects were classified into different groups according to the World Health Organization (WHO) protocol. In this study, in vitro nuclear chromatin decondensation status was assessed in different subgroups of infertile males. The obtained data was then statistically analyzed. RESULTS: Decreased sperm chromatin decondensation was observed in different infertile subgroups compared to the control group ( p < 0.05). Spermatozoa with swollen head indicated a positive response and unswollen head indicated a negative response. CONCLUSIONS: This study asserts that abnormal nuclear decondensation is a potential factor that diminishes the fertilizing capacity of the sperms among different subgroups of infertile males .
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نویسندگان مقاله gopalappa sreenivasa | gopalappa sreenivasa
molecular reproductive and human genetics labratory, department of studies in zoology, university of mysore, manasagangothri, mysore, india


papanna kavitha | papanna kavitha
molecular reproductive and human genetics labratory, department of studies in zoology, university of mysore, manasagangothri, mysore, india


venugopal satidevi vineeth | venugopal satidevi vineeth
molecular reproductive and human genetics labratory, department of studies in zoology, university of mysore, manasagangothri, mysore, india


sharath کومار channappa | sharath kumar channappa
mediwave ivf and fertility research center and semen bank, mysore, karnataka, india


suttur srikanta naik malini | suttur srikanta naik malini
molecular reproductive and human genetics labratory, department of studies in zoology, university of mysore, manasagangothri, mysore, india
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8353
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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