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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۴، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children
چکیده انگلیسی مقاله 1024x768 Normal 0 false false false EN-US X-NONE AR-SA Background: This study aimed to determine the association of particulate matters with endothelial function, measured by flow mediated dilation (FMD) of brachial artery, in children with or without exposure to secondhand smoke. Materials and Methods: This cross-sectional study was conducted from January to March 2011 in Isfahan , which is the second large and air-polluted city in Iran. The areas of the city with lowest and highest air pollution were determined, and i n each area, 25 prepubescent boys with or without exposure to daily tobacco smoke in home w ere selected, i.e. 100 children were studied in total. Results: FMD was significantly smaller in those living in high-polluted area and those exposed to secondhand smoke. Multiple linear regression analysis, adjusted for age and body mass index, showed that both passive smoking status and living area in terms of particulate air pollution were effective determinants of the brachial artery diameter. The standardized coefficient of passive smoking status was - 0.36 (SD = 0.09, P < 0.0001) showing negative association with percent increase in FMD . Likewise, the p ercent increase in brachial artery diameter was lower in passive smoker children. Similar relationship was documented for PM 10 concentration with a regression coefficient of - 0.32 (SD = 0.04, P < 0.0001). Without considering passive smoking variable, PM 10 concentration has significant independent effect on FMD level. Conclusion: Our findings provide evidence on the association of environmental factors on endothelial dysfunction from early life. Studying such associations among healthy children may help identify the underlying mechanisms. The clinical implications of environmental factors on early stages of atherosclerosis should be confirmed in longitudinal studies. Key words: Air pollution, children, endothelium-dependent brachial artery, smoke
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نویسندگان مقاله محمدهاشمی | mohammad hashemi
department of cardiology, faculty of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد رضا افشانی | mohammad reza afshani
department of cardiology, faculty of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مرجان منصوریان | marjan mansourian
department of biostatistics and epidemiology, health, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

پریناز پورصفا | parinaz poursafa
environment research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

رویا کلیشادی | roya kelishadi
faculty of medicine and child health promotion research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8275
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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