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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۰۳، صفحات ۰-۰
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عنوان انگلیسی CD10 expression in stromal component of invasive breast carcinoma: A potential prognostic determinant
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} BACKGROUND : CD10 is a cell surface metalloproteinase which inactivates various biologically active peptides. Earlier studies have suggested CD10 expression in the stroma of various carcinomas to be associated with more aggressive behavior of the tumor. The aim of this study was to assess CD10 expression in stromal component of invasive breast carcinoma and its relationship with well-known clinicopathologic parameters. METHODS : This study included 49 formalin-fixed and paraffin-embedded tissue specimens of invasive breast carcinoma from the pathology archive of a referral hospital. CD10 expression was detected by immunohistochemistry and scored based on the staining intensity and percentage of the stained cells. Kruskal-Wallis and Mann-Whitney tests, along with Spearman's correlation coefficients were used to determine the relationship between CD10 expression and clinicopathologic parameters. RESULTS : No association was found between stromal CD10 expression and age, carcinoma subtype, and HER2/neu status. A significant positive correlation was seen between stromal CD10 expression and tumor size (p = 0.01), axillary lymph node status (p = 0.02), and tumor grade (p = 0.004). Although negative correlations were detected between stromal CD10 expression and estrogen receptor and progesterone receptor status, these correlations were not statistically significant. CONCLUSIONS : Tumor grade is a major prognostic indicator of breast carcinoma. Tumor size and nodal status on the other hand, are important determinants of tumor stage. Therefore, our findings concerning the positive correlations between stromal CD10 expression and tumor grade, tumor size, and nodal status suggest a strong effect of stromal CD10 expression on aggressive behavior of breast carcinoma and introduce this marker as a potential prognostic determinant in breast cancer. KEYWORDS : Invasive Breast Carcinoma, Stroma, CD10
کلیدواژه‌های انگلیسی مقاله invasive breast carcinoma- stroma- CD10
نویسندگان مقاله فرشته محمدی زاده | fereshteh mohammadizadeh
associate professor, department of pathology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مجید صلواتی | majid salavati
resident, department of pathology, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نوشین افشار مقدم | noushin afshar moghaddam
associate professor, department of pathology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8172
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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