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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۰۳، صفحات ۰-۰
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عنوان انگلیسی Role of CYP1A1 MspI polymorphism in CYP1A1 gene with susceptibility to lung cancer in Iranian patients
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 BACKGROUND : Lung cancer has remained the most prevalent malignancy worldwide. It is the fifth leading cause of cancer death in Iran. Nevertheless, during last few years a gradual permanent increase in its incidence has been reported. Although the crucial role of tobacco smoke in lung cancer initiation has long been established, it is tempting to hypothesize that genetic polymorphisms may contribute to lung cancer predisposition. CYP1A1 gene encodes the main enzyme responsible for metabolic activation of several tobacco carcinogens. CYP1A1 Msp I (6235T→C) polymorphism is the most studied variation within the CYP1A1 , impacts on the basal levels of metabolism and is believed to be associated with elevated lung cancer risk, mainly in Asian population. METHODS : We investigated the frequency of this genetic variation in Iranian lung cancer patients through a cross-sectional study. 65 lung cancer cases and 80 healthy controls were recruited. RESULTS : The present findings confirmed the low frequency of the variant CYP1A1*2A allele in the control group. A significant increased risk for lung cancer was observed among those who possessed heterozygous ( *1 / *2A ) genotype (OR = 2.79; 95% CI= 1.01-7.65). Adenocarcinoma was more frequent in non-smoker group (P = 0.00064); however, no significant increased risk obtained for squamous cell carcinoma and small cell carcinoma with respect to smoking. CONCLUSIONS: heterozygous ( *1 / *2A ) genotype may increase the risk of lung cancer. KEYWORDS : Cytochrome P450, Lung Cancer, Polycyclic Aromatic Hydrocarbon, RFLP-PCR, Tobacco Smoke, Iran
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نویسندگان مقاله مجید متولی باشی | majid motovali bashi
assistant professor, department of biology, school of sciences, university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

مصطفی بیگلری | mostafa biglari
department of biology, school of sciences, university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

زهره حجتی | zohreh hojati
assistant professor, department of biology, school of sciences, university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

سیمین همتی | simin hemati
assistant professor, department of radiation oncology, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

کیان خداداد | kian khodadad
assistant professor, chronic respiratory diseases research center, masih daneshvari hospital, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8221
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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