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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۲، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Serologic celiac disease in patients with inflammatory bowel disease
چکیده انگلیسی مقاله BACKGROUND : There is an association of celiac disease (CD) with several gastrointestinal illnesses. We aimed to determine the prevalence of CD in patients with inflammatory bowel disease (IBD) to evaluate the value of the routine serological tests for CD in these patients. METHODS : patients with IBD underwent screening test for CD. The screening test was based on IgA anti-tTG antibody evaluated by ELISA method and IgA EMA (endomysial antibody) measured by the indirect immunofluorescence method. Fisher exact and chi-square and t tests were used for data analysis. RESULTS : the study was conducted on 100 patients, with a mean age of 34.74 ± 12.03 (SD) years. The mean simplified Crohn’s disease activity index was 90 ± 17 (SE) and the mean colitis activity index was 3.46± 0.96 (SE). Seventeen patients (17%) had IgA anti-tTG antibody levels above the cutoff point (> 20). Thirty-two patients were positive for IgA EMA. IgA EMA was positive in nine IgA anti-tTG positive patients (three patients with Crohn’s Disease and six ones with ulcerative colitis). Then, the prevalence of serologic CD was 9% that was higher than that of general population. A significant correlation was found between the results of IgA EMA and those of IgA anti-tTG (p = 0.001) whereas Fisher exact test revealed significant difference between frequency distribution of positive and negative results of IgA EMA and IgA anti-tTG in patients with ulcerative colitis and Crohn’s disease (p < 0.001). CONCLUSIONS : the prevalence of serologic CD in general population in Iran has been reported to be 0.6–0.96%. Then, its prevalence in our sample size was about ten times more than that in general population. KEYWORDS : Celiac Disease, Inflammatory Bowel Disease
کلیدواژه‌های انگلیسی مقاله Celiac disease, Inflammatory bowel disease
نویسندگان مقاله حمید توکلی | hamid tavakkoli
department of gastroenterology, alzahra university hospital, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سعید haghdani | saeid haghdani
poursina hakim research institute, isfahan, iran


هایده هایده | haiedeh adilipour
poursina hakim research institute, isfahan, iran


حامد دقاق زاده | hamed daghaghzadeh
department of gastroenterology, alzahra university hospital, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد میناکاری | mohammad minakari
department of gastroenterology, alzahra university hospital, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

پیمان ادیبی | peyman adibi
department of gastroenterology, alzahra university hospital, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

خلیل احمدی | khalil ahmadi
department of gastroenterology, alzahra university hospital, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد حسن امامی | mohammah hassan emami
department of gastroenterology, alzahra university hospital, isfahan university of medical sciences and poursina hakim research institute, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/6555
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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