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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۱۲، صفحات ۰-۰
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عنوان انگلیسی The effects of sertraline on blood lipids, glucose, insulin and HBA1C levels: A prospective clinical trial on depressive patients
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE FA MicrosoftInternetExplorer4 BACKGROUND : In this study, we aimed to investigate the possible effects of sertraline on blood glucose and lipid levels as risk factors for cardiovascular disease in depressive patients. METHODS : Eight male and twelve female depressive patients, diagnosed according to DSM-IV criteria, were included in this study. The subjects aged 19-50 years, did not smoke, and had normal body mass index (BMI), homeostasis model assessment-estimated insulin resistance ( HOMA-IR) values, blood pressure, blood glucose, insulin and lipid levels. Sertraline therapy (50 mg/day) was started. Patients with diabetes mellitus, heart disease, pregnancy, and those taking other drugs were excluded from the study. Blood glucose, insulin, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride values were measured in patients before, and at the 4th, 8th and 12th weeks after treatment with sertraline . Moreover, HbA1C levels were measured a t the beginning and at the end of the treatment (at 12th weeks). RESULTS : There were no significant differences in physical examination (blood pressure, BMI, body weight, height, waist circumference) and laboratory findings (glucose , HDL-C, LDL-C, HOMA-IR and HbA1C levels) at the 12th week after of treatment with sertraline compared to pretreatment values. However, insulin levels at the 4th, 8th and 12th weeks significantly increased compared with pretreatment values. Likewise, triglyceride levels at the 8th and 12th weeks significantly increased compared with pretreatment values. CONCLUSIONS : Sertraline-treated patients have to be followed up for blood insulin and triglyceride levels. In addition, their treatment plan needs to be adjusted as necessary to prevent possible metabolic changes. KEYWORDS : Sertraline, Insulin, Glucose, Lipid, HbA1C.
کلیدواژه‌های انگلیسی مقاله Sertraline, Insulin, Glucose, Lipid, HbA1C
نویسندگان مقاله مرات kesim | murat kesim
associate professor, department of pharmacology, school of medicine, karadeniz technical university, trabzon, turkey


آحمت tiryaki | ahmet tiryaki
associate professor, department of psychiatry, school of medicine, karadeniz technical university, trabzon, turkey


مینه kadioglu | mine kadioglu
assistant professor, department of pharmacology, school of medicine, karadeniz technical university, trabzon, turkey


efnan muci | efnan muci
department of pharmacology, school of medicine, karadeniz technical university, trabzon, turkey


نوری ihsan kalyoncu | nuri ihsan kalyoncu
professor, department of pharmacology, school of medicine, karadeniz technical university, trabzon, turkey


ersin yaris | ersin yaris
professor, department of pharmacology, school of medicine, karadeniz technical university, trabzon, turkey
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7896
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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