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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۱۱، صفحات ۰-۰
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عنوان انگلیسی The protective role of endogenous nitric oxide donor (l -arginine) in cisplatin-induced nephrotoxicity: Gender related differences in rat model
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE FA MicrosoftInternetExplorer4 BACKGROUND : Cisplatin (CP) as a potential drug for solid tumors produces nephrotoxicity and disturbs endothelial function. CP induced nephrotoxicity may be gender related. Nitric oxide plays a pivotal role in endothelial function and L-arginine as endogenous NO donor promotes endothelial function. The role of L-arginine in CP induced nephrotoxicity model and its gender related was investigated in this study. METHODS : Thirty three Wistar rats were randomly assigned to four groups. The groups 1 (male, n = 6) and 2 (female, n = 11) received a single dose of L-arginine (300 mg/kg, ip), and the day after, they received a single dose of CP (7 mg/kg). The group 3 (male, n = 9) and 4 (female, n = 7) were assigned to the same regimen except for saline instead of L-arginine. All animals were sacrificed one week after CP administration. The levels of blood urea nitrogen (BUN), creatinine and nitrite were measured. The kidneys were also removed for pathological investigations. RESULTS : Five animals died. All CP treated animals lost weight. The normalized weigh loss was significantly different between male and female in CP+L-arginine treated animals (p < 0.05). BUN and creatinine were increased significantly in male treated with CP and in female treated with CP+L-arginine (p < 0.05). L-arginine reduced BUN in male (not in female) when compared with control groups (p < 0.05). The level of nitrite was increased significantly in L-arginine treated animals. Kidney tissue damage score and normalized kidney weight were greater in females treated with CP+L-arginine than female received CP alone (p < 0.05). CONCLUSIONS : L-arginine may protect against CP induced nephrotoxicity in male, but it promotes the induced damage in female. The exact mechanism need to be defined. KEYWORDS : Gender, L-arginine, Cisplatin, Nephrotoxicity, Rat
کلیدواژه‌های انگلیسی مقاله Gender, l-arginine, cisplatin, nephrotoxicity, rat
نویسندگان مقاله فاطمه اشراقی جزی | fatemeh eshraghi jazi
kidney basic sciences research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مهدی نعمت بخش | mehdi nematbakhsh
professor, kidney basic sciences research center and department of physiology, school of medicine and kidney diseases research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

حمید نصری | hamid nasri
professor, kidney diseases research center and department of internal medicine, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

اردشیر طالبی | ardeshir talebi
associated professor, kidney basic sciences research center and department of clinical pathology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مریم حقیقی | maryam haghighi
kidney basic sciences research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

زهرا پزشکی | zahra pezeshki
kidney basic sciences research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

طاهره صفری | tahereh safari
kidney basic sciences research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فرزانه اشرفی | farzaneh ashrafi
assistant professor, department of internal medicine, school of medicine and kidney basic sciences research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7587
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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