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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۱۱، صفحات ۰-۰
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عنوان انگلیسی The effects of moderate-dose steroid therapy in sepsis: A placebo-controlled, randomized study
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE FA MicrosoftInternetExplorer4 BACKGROUND: Despite the new developments in sepsis treatment, mortality rate is still high. In this study, we aimed toinvestigate endocrinologic changes and the effects of moderate dosage steroid treatment in patients with sepsis. METHODS: Fifty-five patients were included in the study. Basal hormonal evaluation and adrenocorticotropin hormone (ACTH) stimulation test were performed within 24 h in all patients. Both groups received standard treatment for sepsis. However, one group (steroid group) was also given intravenous prednisolone (20 mg/day). All-cause mortality was assessed during the first 28 days. RESULTS: Analysis of the findings revealed a 59.3% mortality rate in steroid group compared with a 53.6% mortality rate in placebo group (p = 0.787). Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores, and peak cortisol and ACTH levels were significant factors related to mortality. The incidence of adrenal insufficiency (AI) was 10.9% and relative adrenal insufficiency (RAI) 36.4%. It was also found that steroid treatment did not have any effects on the mortality of patients with AI and RAI (p = 0.075 and p = 0.999, respectively). CONCLUSIONS: Moderate-dose steroid therapy has no effect on mortality. Higher basal cortisol and peak cortisol levels were found more reliable mortality indicators compared to RAI. In addition, the study revealed that ACTH level was a significant indicator of mortality. KEYWORDS: ACTH, Prednisolone, Cortisol, Adrenal Insufficiency, Sepsis.
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نویسندگان مقاله orhan yildiz | orhan yildiz
associate professor, department of infectious diseases, school of medicine, erciyes university, kayseri, turkey.


فتیحه tanriverdi | fatih tanriverdi
associate professor, division of endocrinology, department of internal medicine, school of medicine, erciyes university, kayseri, turkey


serap simsek | serap simsek
consultant, department of infectious diseases, school of medicine, erciyes university, kayseri, turkey


bilgehan aygen | bilgehan aygen
professor, department of infectious diseases, school of medicine, erciyes university, kayseri, turkey


fahrettin kelestimur | fahrettin kelestimur
professor, division of endocrinology, department of internal medicine, school of medicine, erciyes university, kayseri, turkey
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7129
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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