| چکیده انگلیسی مقاله |
Normal 0 false false false EN-US X-NONE FA BACKGROUND : Increased proteinuria would lead to a larger risk for renal failure in the long term. Therefore, proteinuria requires immediate and thorough evaluation. This study was designed to evaluate the effects of pioglitazone on proteinuria in patients with non-diabetic renal disease. METHODS : In this self-controlled clinical trial study, forty four non-diabetic patients aged 18 and more, who had renal disease and a stable proteinuria of over 0.5 g in 24 hour, were studied. All patients received 15 mg of daily pioglitazone for 4 months. Urine protein excretion was measured as a main end point prior to the study, at the end of the 2nd and 4th months of treatment, and 2 and 4 months after the cessation of the active drug. Other evaluated variables included systolic blood pressure, serum creatinine, urea, alanine aminotransferase (ALT), aspartate aminotransferase (AST), fasting blood sugar (FBS), blood urea nitrogen (BUN) and glomerular filtration rate (GFR) levels. RESULTS : Proteinuria (mean ± SEM) prior to the study, at the 2nd and 4th months of the treatment, and 2 and 4 months after the cessation of pioglitazone were 1088.6 ± 131.1, 699.9 ± 118.3, 433.9 ± 68.7, 416.1 ± 54.9 and 646.9 ± 89.1, respectively (p < 0.001). In addition, the reduction of 24-hour urine protein was statistically significant for both male and female patients (p < 0.001 for both). CONCLUSIONS : A reduction of proteinuria in patients with non-diabetic renal disease was observed during the 4-month treatment with pioglitazone which continued for 2 months after the cessation of the treatment. However, 4 months after the cessation of the treatment, a little increase was detected in the level of proteinuria. KEYWORDS : Proteinuria, Pioglitazone, Renal Disease, Thiazolidinediones. |
| نویسندگان مقاله |
شهرزاد شهیدی | shahrzad shahidi
associate professor, isfahan kidney diseases research center, department of internal medicine, school of medicine, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
بهرام پاکزاد | bahram pakzad
internist, isfahan kidney diseases research center, department of internal medicine, school of medicine, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
مژگان مرتضوی | mojgan mortazavi
assistant professor, isfahan kidney diseases research center, department of internal medicine, school of medicine, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
مجتبی اکبری | mojtaba akbari
epidemiologist, school of medicine, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
شیوا صیرفیان | shiva seirafian
associate professor, isfahan kidney diseases research center, department of internal medicine, school of medicine, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
عبدالامیر عطاپور | abdolamir atapour
assistant professor, isfahan kidney diseases research center, department of internal medicine, school of medicine, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
سمیرا al سعیدی | samira al saeidi
internist, department of internal medicine, school of medicine, gonabad university of medical sciences, gonabad, khorasan razavi, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گناباد (Gonabad university of medical sciences)
علیرضا شایگان نژاد | alireza shayegannejad
internist, isfahan kidney diseases research center, department of internal medicine, school of medicine, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
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