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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۱۰، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial
چکیده انگلیسی مقاله 800x600 Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 BACKGROUND : Postanesthetic shivering is one of the most common complications of anesthesia. We compared the efficacy of meperidine and two low doses of ketamine with placebo to prevent postanesthetic shivering after general anesthesia. METHODS : This was a prospective, randomized double-blind placebo controlled clinical trial involving 120 ASA I-II patients aging 20-50 years, undergoing endoscopic sinus surgery with general anesthesia. Patients were randomly allocated to receive meperidine 0.4 mg/kg (Group M, n = 30), ketamine 0.3 mg/kg (Group K 1 , n = 30), ketamine 0.5 mg/kg (Group K 2 , n = 30), or normal saline (Group N, n = 30) 20 minutes before completion of the surgery. Tympanic temperature, blood pressure, and heart rate were measured before and immediately after induction of anesthesia, 30 minutes after induction, and before administration of the study drugs. The drugs were prepared and diluted to a volume of 2 ml and presented as coded syringes. An investigator, blinded to the groups, graded postanesthetic shivering using a four-point scale. Statistical analyses were performed using Statistical Package for Social Sciences (SPSS) Windows version 16. A p-value < 0.05 was considered statistically significant. RESULTS : Patient characteristics of the four groups were similar. The number of patients with observed shivering in groups was 0, 3, 1, and 9 in Groups M, K 1 , K 2 and N, respectively. The difference between groups M, K 1 , and K 2 with Group N was statistically significant. However, differences between groups M and K 1 , M and K 2 , and K 1 and K 2 were not significant. The number of patients with a shivering score of 2 or 3 was higher in Group N compared with other groups. CONCLUSIONS : Prophylactic use of low doses of intravenous ketamine (0.3 or 0.5 mg/kg) was found to be effective to prevent postanesthetic shivering. However, administration of 0.3 mg/kg ketamine lowered the rate of hallucination as compared with 0.5 mg/kg. KEYWORDS : Postanesthetic Shivering, Meperidine, Ketamine.
کلیدواژه‌های انگلیسی مقاله Postoperative Shivering, Meperidine, Ketamine
نویسندگان مقاله ویدا آیت اللهی | vida ayatollahi
associate professor, department of anesthesiology, school of medicine, shahid sadoughi university of medical sciences and health services, yazd, iran


محمد رضا حاجی اسماعیلی | mohammad reza hajiesmaeili
resident, department of anesthesiology, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شکوفه بهداد | shekoufeh behdad
associate professor, department of anesthesiology, school of medicine, shahid sadoughi university of medical sciences and health services, yazd, iran


محمد قلی پور | mohammad gholipur
anesthesiologist, department of anesthesiology, school of medicine, kermanshah university of medical sciences and health services, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

حمید رضا عباسی | hamid reza abbasi
associate professor, department of anesthesiology, school of medicine, shahid sadoughi university of medical sciences and health services, yazd, iran
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7042
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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