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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۸، صفحات ۰-۰
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عنوان انگلیسی Comparative study of MDA and vitamin C in non-smokers, chronic smokers and chronic smokers with acute myocardial infarction
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA BACKGROUND : It is a well known fact that there is increased oxidative stress and decreased serum antioxidant levels in smokers than in non-smokers. In this study, the aim was to compare the malondialdehyde (MDA), a lipid peroxidation product and vitamin C, an antioxidant, between non- smokers (Group A) and chronic smokers (Group B) and also between chronic smokers (Group B) and chronic smokers with acute myocardial infarction (AMI) (Group C). M ٍ ETHODS: Thirty six non-smokers and 36 chronic smokers appropriately matched with AMI patients were selected. Thirty six smokers with AMI were selected from Hanagal Kumareshwara hospital, Bagalkot, Karnataka, India. Fasting blood sample was collected in group A and group B. In AMI patients, blood sample was collected before any intervention. Serum levels of MDA and vitamin C were estimated. Statistical analysis was done by t test using SPSS version 11. p< 0.05 was considered statistically significant. All the results were expressed as mean ± SD. RESULTS: The MDA and vitamin C were compared between Group A and Group B and also between Group B and Group C. There was a significant rise in MDA (p < 0.0001) and significant decrease in vitamin C (p < 0.01) in Group B compared to Group A. There was a significant rise in MDA (p < 0.0001) and significant decrease in vitamin C (p < 0.001) in Group C compared to Group B. CONCLUSIONS: The increase in serum MDA levels and decrease in vitamin C was found in chronic smokers compared to non-smokers. It was also found that there is increase in serum MDA and decrease in vitamin C in smokers with AMI compared with smokers without MI. The inter-subject variability of MDA and vitamin C levels may be because of gene-environmental factors. KEYWORDS : Chronic smokers, Myocardial infarction, MDA, Vitamin C.
کلیدواژه‌های انگلیسی مقاله Chronic smokers, Myocardial infarction, MDA, Vitamin C.
نویسندگان مقاله sangappa virupaxappa kashinakunti | sangappa virupaxappa kashinakunti
associate professor, department of biochemistry, s.n. medical college bagalkot, karnataka, india.


pampareddy kollur | pampareddy kollur
assistant professor, deparmentt of biochemistry, d. y. patil medical college kolhapur, maharashtra, india.


gurupadappa shantappa kallaganada | gurupadappa shantappa kallaganada
professor and hod, department of biochemistry, s. nijalingappa medical college bagalkot, karnataka, india.


manjula rangappa | manjula rangappa
assistant professor, department of community medicine, s.n. medical college bagalkot, karnataka, india.


jagadish basavaraj ingin | jagadish basavaraj ingin
professor and hod, department of biochemistry, m.r. medical college gulbarga, karnataka. india
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7211
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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