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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۸، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی In vitro and in vivo activities of Peganum harmala extract against Leishmania major
چکیده انگلیسی مقاله BACKGROUND: In vitro and in vivo antileishmanial activities of crude hydroalcoholic extract of peganum harmala seeds were investigated against Leishmania major. METHODS: The extract of aerial parts of P harmala was obtained by maceration. The in vitro experiments were per- formed on promastigotes to assess antileishmanial activity of the extract using amphotericin B as a reference. The in vivo studies were carried out on cutaneous leishmaniasis in outbred mice to evaluate the effects of topical application of the ointment-based extract. RESULTS: The in vitro experiments showed a concentration-dependent decrease of parasites number caused by the ex- tract with an IC50 value of 59.4 g/ml. In vivo studies demonstrated a significant post-treatment decrease in the lesion size and parasite count in infected animals, compared to placebo and control groups. High performance liquid chroma- tography (HPLC) of the crude extract demonstrated the existence of harmaline and harmine as beta-carboline alkaloids. CONCLUSIONS: P harmala seeds extract showed significant in vitro and in vivo antileishmanial activities. Most biologi- cal activity of the extract could be attributed to its beta-carboline content. However, another alkaloid of P harmala seeds extract, peganine, has also been reported to have antileishmanial activity. These beneficial effects can be attri- buted to the cumulative effects of various biologically active components present in it.
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نویسندگان مقاله پروانه رحیمی مقدم | parvaneh rahimi moghaddam
assistant professor, department of pharmacology, razi institute for drug research, medical school, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سلطان احمد ابراهیمی | soltan ahmad ebrahimi
associate professor, department of pharmacology, razi institute for drug research, medical school, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

hourmazd اورمزدی | hourmazd ourmazdi
professor, department of parasitology and mycology, medical school, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

منور سلسله | monavvar selseleh
department of parasitology and mycology, medical school, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مریم کرجالیان | maryam karjalian
department of pharmacology, razi institute for drug research, medical school, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

گیتی حاج حسنی | giti haj hassani
department of pharmacology, razi institute for drug research, medical school, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد حسین علیمحمدیان | mohammad hossein alimohammadian
professor, iran pasture institute, tehran, iran


مسعود محمودیان | massoud mahmoudian
professor, department of pharmacology, razi institute for drug research, medical school, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

معصومه شفیعی | massoumeh shafiei
associate professor, department of pharmacology, razi institute for drug research, medical school, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/6650
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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