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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۷، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی The effect of omega-3 fatty acids on serum paraoxonase activity, vitamins A, E, and C in type 2 diabetic patients
چکیده انگلیسی مقاله BACKGROUND: Diabetes mellitus is a heterogeneous metabolic disorder characterized by hyperglycemia. Studies showed paraoxonase activity, and vitamin C and A levels are decreased in diabetes . The effect of omega-3 fatty acids on serum paraoxonase activity and vitamins A, E, C in patients with type 2 diabetes is not fully understood. This study aimed to determine the effect of omega-3 fatty acids on paraoxonase activity, vitamins C, A and E levels in type 2 diabetic patients. METHODS: In a double-blind, placebo controlled trial, 80 type 2 diabetic patients were randomly enrolled into the study. Study subjects received daily 2714 mg of omega-3 fatty acids or placebo for 8 weeks. Ten milliliter fasting blood was collected before and after treatments. Serum paraoxonase activity and vitamin C levels were measured by spectrophotometry. Vitamin A and vitamin E were measured using high performance liquid chromatography . Nutrient intake was estimated using 24-hours dietary recall questionnaire (for 2 days) before and after treatments. Dietary data were analyzed using FPII. To compare the means of variables between the two groups, independent t-test was employed. Differences between variables before and after interventions were calculated using paired t-test. RESULTS: Serum levels of paraoxonase activity were significantly increased after omega-3 intake (126.47 IU/ml vs. 180.13 IU/ml). However, omega-3 intake caused no significant change in serum vitamin A, C, and E. CONCLUSIONS: Supplementation of omega-3 fatty acids was found to increase paraoxonase activity in diabetic patients. KEYWORDS: Paraoxonase, Diabetes mellitus, Vitamin C, Vitamin A, Vitamin E .
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نویسندگان مقاله انیس کوچک | anis kouchak
department of nutrition and biochemistry, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمود جلالی | mahmoud djalali
department of nutrition and biochemistry, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدرضا اشراقیان | mohamadreza eshraghian
department of biostatistics, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

احمد ساعدی صومعه علیا | ahmad saedisomeolia
department of nutrition and biochemistry, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ابوالقاسم جزایری | abolghassem djazayery
department of nutrition and biochemistry, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حسین حاجیان فر | hossein hajianfar
department of nutrition and biochemistry, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/6319
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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