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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۷، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparison of polyomavirus (BK virus and JC viruses) viruria in renal transplant recipients with and without kidney dysfunction.
چکیده انگلیسی مقاله BACKGROUND: Post-transplant infection with polyoma viruses (BK and JC viruses) is an important cause of graft loss and nephropathy. The objective of this study was to compare the frequency of BK and JC viruria in renal transplant recipients with and without graft dysfunction. METHODS: In a case-control study, we selected 60 kidney transplant patients with and without graft dysfunction in the first two years after transplantation. Each group consisted of 30 patients evaluated for basic demographic and laboratory characteristics. First morning urine samples were sent for BK and JC virus detection with QIAamp DNA Mini Kit and real-time polymerase PCR. Chi-square test with Yates’ correction, Student t-test and Mann-Whitney U test were used as indicated. P value of less than 0.05 was regarded as statistically significant. RESULTS: Both groups were similar in age, gender, and time after transplant and pretransplant dialysis. In both groups, seven patients (23.3%) were JC virus positive whereas in case group 14 patients (46.7%) and in control group 9 patients (30%) were BK virus positive. There were no statistical significant difference between case and control groups for both JC and BK virus infection rate. CONCLUSIONS: We concluded that JC and BK virus infection is very prevalent in the first 2 years after transplant and might be monitored appropriately. KEYWORDS: PolyomaVirus, BK virus, JC Virus, Renal Transplantation, PCR. BACKGROUND: Post-transplant infection with polyoma viruses (BK and JC viruses) is an important cause of graft loss and nephropathy. The objective of this study was to compare the frequency of BK and JC viruria in renal transplant recipients with and without graft dysfunction. METHODS: In a case-control study, we selected 60 kidney transplant patients with and without graft dysfunction in the first two years after transplantation. Each group consisted of 30 patients evaluated for basic demographic and laboratory characteristics. First morning urine samples were sent for BK and JC virus detection with QIAamp DNA Mini Kit and real-time polymerase PCR. Chi-square test with Yates’ correction, Student t-test and Mann-Whitney U test were used as indicated. P value of less than 0.05 was regarded as statistically significant. RESULTS: Both groups were similar in age, gender, and time after transplant and pretransplant dialysis. In both groups, seven patients (23.3%) were JC virus positive whereas in case group 14 patients (46.7%) and in control group 9 patients (30%) were BK virus positive. There were no statistical significant difference between case and control groups for both JC and BK virus infection rate. CONCLUSIONS: We concluded that JC and BK virus infection is very prevalent in the first 2 years after transplant and might be monitored appropriately. KEYWORDS: Polyoma Virus, BK Virus, JC Virus, Renal Transplantation, PCR.
کلیدواژه‌های انگلیسی مقاله Polyomavirus, BK virus, JC virus, renal transplantation, PCR
نویسندگان مقاله شهرام طاهری | shahram taheri
associate professor, isfahan kidney diseases research center, internal medicine department, isfahan university of medical sciences isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فرشید کفیل زاده | farshid kafilzadeh
associated professor, department of biology, jahrom branch, islamic azad university, jahrom, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مریم شفا | maryam shafa
master of science, department of biology, jahrom branch, islamic azad university, jahrom, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مجید یاران | majid yaran
medical laboratory doctor, infectious diseases and tropical medicine research center, isfahan university of medical science, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

مژگان مرتضوی | mojgan mortazavi
assistant professor, isfahan kidney diseases research center, internal medicine department, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

شیوا صیرفیان | shiva seirafian
associate professor, isfahan kidney diseases research center, internal medicine department, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

شهرزاد شهیدی | shahrzad shahidi
associate professor, isfahan kidney diseases research center, internal medicine department, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

عبدالامیر عطاپور | abdolamir atapour
assistant professor, isfahan kidney diseases research center, internal medicine department, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/6870
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