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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۶، صفحات ۰-۰
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عنوان انگلیسی Genetic variation in the association of air pollutants with a biomarker of vascular injury in children and adolescents in Isfahan, Iran
چکیده انگلیسی مقاله BACKGROUND: Some experimental studies revealed that exposure to air pollution increases the expression of tissue factor (TF) in atherosclerotic lesions. We aimed to investigate the role of TF +5466A>G (rs3917643) polymorphism in the association of air pollution on serum levels of TF as a biomarker of vascular injury in children. METHODS: This cross-sectional study was conducted among 110 children, consisting of 58 (52.8%) girls and 52 (47.2%) boys with a mean age of 12.7 + 2.3 years, living in Isfahan, Iran. Enzyme-linked immunosorbent assay were used for measurement of serum TF. Genotype of +5466A>G (rs3917643) polymorphism was determined by the polymerase chain reaction–restriction length fragment polymorphism (PCR–RFLP) method. RESULTS: We identified 2 individuals with +5466AG genotype and 108 homozygous for the +5466A allele (no +5466GG homozygotes). The mean pollution standards index (PSI) value was at moderate level, the mean particular matter measuring up to 10 μm (PM 10 ) was more than twice the normal level. Multiple linear regression analysis showed that after adjustment for confounding factors (weight status, dietary and physical activity pattern), serum TF level had significant relationship with PSI (beta: 0.55, SE: 0.07, P < 0.001) and PM 10 (beta: 0.51, SE: 0.03, P = 0.001). CONCLUSION: In spite of similar genetic polymorphism of TF, air pollutants might have an independent association with systemic inflammatory and coagulation responses. The harmful effects of air pollutants on the first stages of atherosclerosis in the pediatric age group should be underscored in primordial and primary prevention of chronic diseases.
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نویسندگان مقاله پریناز پورصفا | parinaz poursafa
environmental protection engineer, department of environment and energy, science and research branch, islamic azad university, tehran and environmental protection engineer, environment research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

رویا کلیشادی | roya kelishadi
professor of pediatrics, department of pediatrics, child health promotion research center and professor of pediatrics, department of pediatrics, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فرامرز معطر | faramarz moattar
professor, faculty of environment and energy, science and research branch , islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

لاله رفیعی | laleh rafiee
research assistant, department of physiology, applied physiology research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد مهدی امین | mohammad mehdi amin
associate professor of environmental health engineering, department of environmental health engineering, environment research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

احمدرضا لاهیجان زاده | ahmadreza lahijanzadeh
isfahan provincial directorate of environmental protection, environmental protection department, isfahan, iran


شقایق حقجو جوانمرد | shaghayegh haghjooy javanmard
assistant professor of physiology, department of physiology, applied physiology research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7260
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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