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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۶، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Antihyperlipidemic activities of Pleurotus ferulae on biochemical and histological function in hypercholesterolemic rats
چکیده انگلیسی مقاله BACKGROUND: Pleurotus ferulae is an edible mushroom has been widely used for nutritional and medicinal purposes. Irrespective of the medicinal importance or therapeutic potentials of Pleurotus ferulae , there have not been studies on antihyperlipidemic properties. Therefore, the present study investigates the effects of dietary Pleurotus ferulae fruiting bodies on plasma and feces biochemical and on the liver histological status in hypercholesterolemic rats. METHODS: Six weeks old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Then biochemical and histological examinations were performed. RESULTS: Feeding of a diet containing 5% Pleurotus ferulae fruiting bodies to hypercholesterolemic rat reduced plasma total cholesterol, triglyceride, low-density lipoprotein (LDL), total lipid, phospholipids, and LDL/high-density lipoprotein ratio by 30.02, 49.31, 71.15, 30.23, 21.93, and 65.31%, respectively. Mushroom also significantly reduced body weight in hypercholesterolemic rats. However, it had no adverse effects on plasma albumin, total bilirubin, direct bilirubin, creatinin, blood urea nitrogen, uric acid, glucose, total protein, calcium, sodium, potassium, chloride, inorganic phosphate, magnesium, and enzyme profiles. Feeding mushroom increased total lipid and cholesterol excretion in feces. The plasma lipoprotein fraction, separated by agarose gel electrophoresis, indicated that Pleurotus ferulae significantly reduced plasma β and pre-β-lipoprotein, while increased the α-lipoprotein. A histological study of hepatic cells by conventional hematoxylin-eosin and oil red O staining showed normal findings for mushroom-fed hypercholesterolemic rats. CONCLUSIONS: The present study suggests that 5% Pleurotus ferulae diet supplement provides health benefits, at least partially, by acting on the atherogenic lipid profile in hypercholesterolemic rats. KEYWORDS: Agarose Gel Electrophoresis, Atherogenic Lipid Profile, Histopathology, Hypercholesterolemic Rats, Pleurotus Ferulae .
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله nuhu عالم | nuhu alam
phd student, division of life sciences, university of incheon, incheon, republic of korea and associate professor, department of botany, jahangirnagar university, savar, dhaka, bangladesh


ki نام yoon | ki nam yoon
phd student, division of life sciences, university of incheon, incheon, republic of korea


tae soo lee | tae soo lee
professor, division of life sciences, university of incheon, incheon, republic of korea
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7021
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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