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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۶، صفحات ۰-۰
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عنوان انگلیسی DNA-methyltransferase 3B 39179 G > T polymorphism and risk of sporadic colorectal cancer in a subset of Iranian population
چکیده انگلیسی مقاله BACKGROUND: Epigenetic event is a biological regulation that influences the expression of various genes involved in cancer. DNA methylation is established by DNA methyltransferases, particularly DNAmethyltransferase 3B (DNMT3B). It seems to play an oncogenic role in the creation of abnormal methylation during tumorigenesis. The polymorphisms of the DNMT3B gene may influence DNMT3B activity in DNA methylation and increase the susceptibility to several cancers. These genetic polymorphisms have been studied in several cancers in different populations. METHODS: In this study, we performed a case–control study with 125 colorectal cancer patients and 135 cancer-free controls to evaluate the association between DNMT3B G39179T polymorphism (rs1569686) in the promoter region and the risk of sporadic colorectal cancer. Up to now, few studies have investigated the role of this gene variant in sporadic colorectal cancer with no familial history of other related cancers. The genotypes of DNMT3B G39179T polymorphism was analyzed by PCR-RFLP. RESULTS: We found that compared with G allele carriers, statistically the DNMT3B TT genotype (%34) was signiï‌cantly associated with increased risk of colorectal cancer (adjusted OR, 3.993, 95% CI, 1.726-9.238, p = 0.001). Compared with DNMT3B TT genotype, the GT and GG genotypes had lower risk of developing sporadic colorectal cancer (OR = 0.848, 95% CI = 0.436-1.650). CONCLUSIONS: Our findings were consistent with that of previously reported case–control studies with colorectal cancer. These results suggest that the DNMT3B G39179T polymorphism influences DNMT3B expression, thus contributing to the genetic susceptibility to colorectal cancer. Further studies are needed to unravel the basic molecular mechanisms.
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نویسندگان مقاله عبدالرضا دارایی | abdolreza daraei
department biomedical sciences, division of of genetics, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

رسول صالحی | rasoul salehi
department biomedical sciences, division of of genetics, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فایزه محمد هاشم | faezeh mohamadhashem
department biomedical sciences, division of of genetics, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7109
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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