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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۶، صفحات ۰-۰
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عنوان انگلیسی Primary bone lymphoma: a clinicopathological retrospective study of 28 patients in a single institution
چکیده انگلیسی مقاله BACKGROUND: Primary bone lymphoma (PBL) is a rare disease and distinct clinicopathological entity. The optimal treatment strategy is still unclear. Because of rarity of PBL, we report our institute experience in PBL clinicopathological feature and treatment results. METHODS: 28 patients diagnosed with PBL were referred to Omid Hospital, cancer research center (CRC), between March 2001 and February 2009. Immunophenotype studies on 16 out of 28 pathological blocks were performed. We analyzed disease free survival (DFS) and overall survival (OS) rates. RESULTS: 14 patients with PBL were analyzed retrospectively. 17 patients (60.7%) were male and 11 (39.3%) were female with a median age of 41 years (range: 11-79). Long bones were the most primarily site of involvement (71%). 26 (93%) patients had diffuse large B cell lymphoma and 2 (7%) had small lymphoblastic lymphoma. One (3%) patient received radiation alone, 18 (66%) cases received combined modality (chemotherapy + radiotherapy) and 8 (30%) received only chemotherapy during their treatment period. The median follow up was 18 months (range: 1-82). Mean DFS was 51 months (range: 37-66). Overall survival (OS) was 54 months (range: 40-68). OS was significantly better in the chemoradiotherapy group compared with other two groups (64 versus 27 months, respectively, p = 0.014). DFS was also significantly better in combined modality arm compared with other two groups (64 versus 21 months, respectively, p = 0.003). CONCLUSIONS: In spite of small number of patients reported in this study, combined modality treatment (chemotherapy and radiotherapy) was shown to be useful as an effective treatment strategy in PBL.
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نویسندگان مقاله محمد رضا قوام نصیری | mohammad reza ghavam nasiri
cancer research center c.r.c , department of radiation oncology, omid hospital, mashhad university of medical science, mashhad, iran


فاطمه ورشویی تبریزی | fatemeh varshoee tabrizi
cancer research center c.r.c , department of radiation oncology, omid hospital, mashhad university of medical science, mashhad, iran


سمیرا محتشمی | samira mohtashami
cancer research center c.r.c , department of radiation oncology, omid hospital, mashhad university of medical science, mashhad, iran


حمید رضا راضیه | hamid reza raziee
cancer research center c.r.c , department of radiation oncology, omid hospital, mashhad university of medical science, mashhad, iran


امیر آل داوود | amir aledavood
cancer research center c.r.c , department of radiation oncology, omid hospital, mashhad university of medical science, mashhad, iran


کامران غفارزادگان | kamran ghafarzadegan
department of pathology, omid hospital, mashhad university of medical science, mashhad, iran


بهرام معمار | bahram memar
department of pathology, omid hospital, mashhad university of medical science, mashhad, iran


سهیل وجدانی | soheil vojdani
department of radiation, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مصطفی sarvizadeh | mostafa sarvizadeh
department of radiation, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/6606
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communications
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