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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۵، صفحات ۰-۰
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عنوان انگلیسی Fish oil increases atherosclerosis and hepatic steatosis, although decreases serum cholesterol in Wistar rat
چکیده انگلیسی مقاله Background: It is known that fish oil consumption decreases incidence of cardiovascular disease. However, some studies showed that it increases atherosclerosis as it doesn’t get completely metabolized by the liver. The aim of the present study was to investigate the effects of fish oil on aortic atherosclerosis, hepatic steatosis and serum lipids in rats. Methods: Twenty pregnant Wistar rats were fed with a fish oil-containing diet or standard diet (containing soy bean oil) during pregnancy and lactation and the pups were weaned onto the same diet. Fasting blood samples, hepatic and aortic specimens were taken from pups on day 70 postnatal. Data were analyzed with SPSS software, using t-test, Mann-Whitney test and Spearman correlation coefficient. Values of P< 0.05 were considered significant. Results: Medians for fatty streak in aorta of fish oil fed and soy bean oil fed pups were 1.00 and 0.00, respectively, and P value was 0.042. Also, medians for ductular cell hyperplasia of liver in fish oil fed and soy bean oil fed pups were 1.00 and 0.00, respectively, and P value was 0.014. Total cholesterol in pups fed with fish oil was 52.20 mg/dl and in pups fed with soy bean oil was 83.90 mg/dl (p < 0.00) and for low density lipoprotein cholesterol (LDL-C) values were 8.79 mg/dl and 13.16 mg/dl, respectively (p = 0.031). Conclusion: According to the results of the present study, a diet which provided 15.9% of energy from fish oil as the only source of dietary fat, induced aortic atherosclerosis as well as hepatic steatosis in Wistar rat, although it decreased total cholesterol and LDL-C. Key words: Fish Oil, Omega-3, Liver, Aorta .
کلیدواژه‌های انگلیسی مقاله fish oil, omega-3, liver, aorta
نویسندگان مقاله مینو محمد شیرازی | minoo mohammad shirazi
assistant professor of clinical nutrition, department of clinical nutrition and dietetics,national nutrition and food technology research institute,school of nutrition science and food technology,shahid beheshti university of medical sciences,tehran,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

فروغ اعظم طالبان | fourugh azam taleban
professor of clinical nutrition, clinical nutrition and dietetics department, national nutrition and food technology research institute, school of nutrition science and food technology, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

علی رضا آبادی | ali reza abadi
associate professor, department of social medicine, school of medicine, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

دکتر معصومه ثابت کسایی | masoumeh sabetkasaei
professor, department of pharmacology, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7091
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زبان مقاله منتشر شده en
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