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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۵، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The evaluation of Tetanus-diphtheria (Td) vaccine impacts on immune response to hepatitis B (HB) vaccine in non-responder dialysis patients
چکیده انگلیسی مقاله Abstract Background :The Hepatitis B(HB) vaccine response in hemodialysis patients is less than healthy individuals. Different strategies have been taken to improve the response rate. The aim of this study is to evaluate the effect of tetanus and diphtheria (Td) vaccine as an adjuvant therapy to HB vaccination. Methods and Materials :We recruited 63 patients who had passed at least 3 dose HB vaccination schedule , and had HBS Antibody (Ab) titer less than 10 IU/L. The patients were divided into two groups, A(30 patients) and B(33 patients). Both of them received a 3 dose HB vaccination schedule of 40µgr intramuscularly in the left deltoid muscle at 0, 1 and 6 months. Group A, also recieved Td vaccine intramuscularly simultaneous with first dose of HB vaccine. HBS Ab was measured in periods of 1 and 6 month after completion of vaccination. Results :One month after completion of vaccination, group A had better but not significant response rate than group B (96% vs 83.9%) (p>0.05), also after 6 month there was no difference between two groups(87.5% vs 83.3%) (p>0.05).Patients with HCV infection had lower response rate than patients who did not have HCV infection(33.3% vs 92.5) (p< 0.05).Younger patients had better response rate than older individuals(r= 0.339 ,P= 0.005). Conclusion : The use of Td vaccine simultaneous with HB vaccination may increase the response rate in non-responder individuals, but it seems not to have any role in the persistence of immune response. Age and HCV infection negatively affect the response to HB vaccination in dialysis patients. Background: The Hepatitis B (HB) vaccine response in hemodialysis patients is less than healthy individuals. Different strategies have been taken into account to improve the response rate. This study aimed to evaluate the effect of tetanus and diphtheria (Td) vaccine as an adjuvant therapy to HB vaccination. Methods: Sixty three end-stage renal disease patients were recruited on dialysis that were older than 18 years and had passed at least 3 doses of HB vaccination schedule, and had HBS antibody (Ab) with titer less than 10 IU/L. The patients were divided into two groups; A (30 patients) and B (33 patients). Both of the groups received a 3-dose HB vaccination schedule of 40 µ g intramuscularly in the left deltoid muscle at 0, 1 and 6 months. Group A also received Td vaccine intramuscularly simultaneous with the first dose of HB vaccine. HBS Ab was measured in periods of 1 and 6 months after completion of the vaccination. Results: One month after completion of the vaccination, group A had better but not significant response rate than group B (96% vs. 83.9%) (p > 0.05); in addition, after 6 month there was no difference between the two groups (87.5% vs. 83.3%) (p > 0.05). Patients with HCV infection had lower response rate than patients who did not have HCV infection (33.3% vs. 92.5%) (p < 0.05). Age had negative effect on immune response to HB vaccination (r = -0.339 and p = 0.005). Conclusion: The use of Td vaccine concurrent with HB vaccination may increase the response rate in non-responder individuals; however, it seems it does not have any role in the persistence of immune response. Age and HCV infection negatively affected the response to HB vaccination in dialysis patients. Keywords: Hemodialysis, Peritoneal Dialysis, Hepatitis B Vaccine, Tetanus-Diphtheria Vaccine
کلیدواژه‌های انگلیسی مقاله Hemodialysis, peritoneal dialysis, HB vaccine, Td vaccine
نویسندگان مقاله شهرزاد شهیدی | shahrzad shahidi
associate professor of nephrology, isfahan kidney diseases research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نسرین نامداری قره قانی | nasrin namdari ghareghani
resident of internal medicine, student research committee, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مژگان مرتضوی نجف آبادی | mojgan mortazavi najafabadi
assistant professor of nephrology, isfahan kidney diseases research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سمیه صادقی حداد زواره | somaye sadeghi hadad zavare
resident of internal medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

رضا عادلی | reza adeli
department of chemical engineering, isfahan university of technology, isfahan, iran

سازمان اصلی تایید شده: دانشگاه صنعتی اصفهان (Isfahan university of technology)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/6890
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