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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۵، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی The effects of bare metal versus drug-eluting stent implantation on circulating endothelial cells following percutaneous coronary intervention
چکیده انگلیسی مقاله BACKGROUND : The purpose of this study was to compare the effects of bare metal stents (BMS) and drug-eluting stents (DES) implantation on circulating endothelial cells (CECs) which have been proposed as cellular markers of endothelial dysfunction following percutaneous coronary intervention (PCI). Recently, it has been established that DES further reduce restenosis and revascularization rate compared to bare metal stents in elective procedures. However, its benefits are compromised by the stent-related thrombosis events. METHODS : 22 patients who were candidate of PCI were included in this study. The patients underwent DES implantation (n = 11) or BMS implantation (n = 11). In all patients the numbers of CECs were determined before and a week after stent implantation using flow cytometry and the obtained data were compared within and between groups by paired and unpaired Student's t-test, respectively. CECs were defined as cells negative for CD45 (FITC) and highly double positive for CD146 (PE) and CD34 (PE-Cy5) expression. RESULTS : There were no significant differences in the baseline levels of CECs between two groups (p = 0.96). Stent implantation led to a significant increase in CECs compared with the preprocedural levels in the BMS group (p = 0.005) whereas there was a significant decrease in CEC numbers in DES group (p = 0.00). One week after stent implantation CECs count in BMS group was significantly higher compared to DES group (p = 0.000). CONCLUSIONS : The results indicate that patients undergoing DES implantation were subjected to less endothelial injury than patients receiving BMS as indicated by CEC enumeration. KEYWORDS : Angioplasty, Balloon, Coronary, Drug-Eluting Stents, Endothelial Cells.
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نویسندگان مقاله سید محمد هاشمی جزی | seyed mohammad hashemi jazi
applied physiology research center, department of physiology and department of cardiology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سعید شفیعی | saeed shafiei
applied physiology research center, department of physiology, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سید حمید زرکش اصفهانی | seyed hamid zarkesh esfahani
applied physiology research center, department of physiology and department of immunology, school of medicine, isfahan university of medical sciences and department of biology, school of sciences, the university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سامان ملکی ورکی | saman maleki vareki
department of biology, school of sciences, the university of isfahan, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

شقایق حقجو جوانمرد | shaghayegh haghjooy javanmard
applied physiology research center, department of physiology, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/6957
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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