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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۵، صفحات ۰-۰
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عنوان انگلیسی Correlation of spot urine protein-creatinine ratio with 24-hour urinary protein in type 2 diabetes mellitus patients: a cross sectional study
چکیده انگلیسی مقاله Background: Diabetic nephropathy is the major cause for chronic renal failure (CRF) and proteinuria is an independent risk factor for end stage renal disease. Hence, early identification and quantification of proteinuria is of prime importance in the diagnosis and management. Methods: This study was conducted amongst 42 diabetic subjects from HSK hospital, Bagalkot. Twenty four-hour urine protein and r a n d o m u r i n e protein to creatinine ratio (P:C) was determined. Pearson’s correlation, sensitivity, specificity, positive and negative predictive values were determined using 24-hour urinary protein as a gold standard for spot urine P:C ratio. ROC curve and area under curve was also determined using SPSS (11.5) software. All the results were expressed in mean ± SD. Results: Forty two diabetes mellitus patients participated in this study. The average of 24 hour urinary protein was 1.6 ± 1.7 gm/day. The spot urine P:C ratio was 1.27 ± 1.55. There was a positive correlation between 24 hours urinary protein and spot urine P:C ratio (r = 0.925, p < 0.0001). The area under the ROC curve for urine P:C ratio at various cutoff was 0.947 (95% confidence interval: 0.831-0.992, p < 0.0001). The sensitivity and specificity was 80.65% and 100% respectively at P:C ratio cutoff of 0.3. Conclusion: The random urine P:C ratio predicts the amount of 24-hour urinary protein excretion with high accuracy. Hence it can be used as a faster diagnostic substitute for 24-hour urinary protein estimation. Key Words: Type 2 Diabetes Mellitus, 24-Hour Urine, Urine Protein to Creatinine Ratio.
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نویسندگان مقاله satish basanagouda biradar | satish basanagouda biradar
assistant professor, department of general medicine, s. nijalingappa medical college, bagalkot, karnataka, india


gurupadappa shantappa kallaganad | gurupadappa shantappa kallaganad
professor and hod, department of biochemistry, s. nijalingappa medical college, bagalkot, karnataka, india


manjula rangappa | manjula rangappa
assistant professor, department of community medicine, s. nijalingappa medical college, navanagar, bagalkot-587102. karnataka, india


sangappa virupaxappa kashinakunti | sangappa virupaxappa kashinakunti
associate professor, department of biochemistry, s. nijalingappa medical college, navanagar, bagalkot-587102.karnataka, india


revathy retnakaran | revathy retnakaran
biostatistician, department of community medicine, shimoga institute of medical sciences, shimoga- 577201, karnataka, india
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7122
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