| چکیده انگلیسی مقاله |
Background: To compare the early and late cardiovascular events as well as side effects of Osvix, a generic form of Clopidogrel versus Plavix regimens in patients with chronic stable angina, undergoing bare metal stent (BMS) or drug eluting stent (DES) placement, this study was carried out. Methods: A total of 442 patients with chronic stable angina who were scheduled for elective percutaneous coronary intervention (PCI) were included in a randomized, double blind, multi-centric clinical trial being performed in 6 distinct university hospitals in 5 cities of Iran from March 2007 to November 2009. Baseline, demographic and history of risk factors were recorded using the patients’ medical charts. Stenting procedure was performed via approach using low contrast agents. Patients underwent BMS or DES placements based on the physician selection and were randomly assigned to Osvix or Plavix groups. Patients were followed by telephone in 0 and 6 months intervals regarding the major adverse cardiovascular events (MACE) including death, myocardial infarction, in-stent thrombosis, stroke, target lesion revascularization, and target vascular revascularization. A ngina episodes, bleeding, liver enzymes, neutrophils and platelets count were also assessed in these intervals. Results: There was not any significant difference between these two groups regarding the baseline characteristics. In the DES group, the 6-month mortality rate and the incidence of MACE in Osvix and Plavix groups were 0.9% and 1.9% (p = 0.61) and 1.8% and 4.9% (p = 0.26), respectively. During the follow up period after DES or BMS placement, there wasn’t any significant difference regarding neutrophil and platelet counts or liver enzymes between study groups. Conclusion: Using Osvix and Plavix are followed by similar major cardiovascular events and side-effect profile in patients undergoing PCI. |
| نویسندگان مقاله |
علی رضا خسروی | ali reza khosravi
isfahan hypertension research center, isfahan cardiovascular research institute, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
مسعود pourmoqhadas | masoud pourmoqhadas
isfahan cardiovascular research center, isfahan cardiovascular research institute, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
محمد استوان | mohammad ostovan
shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
گیلدا کیانی مهر | gilda kiani mehr
isfahan cardiovascular research center, isfahan cardiovascular research institute, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
مژگان قاری پور | mojgan gharipour
isfahan cardiovascular research center, isfahan cardiovascular research institute, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
حبیب ذاکری | habib zakeri
fasa university of medical sciences, fasa, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی فسا (Fasa university of medical sciences)
بهرام سلیمانی | bahram soleimani
school of medicine, najafabad branch, islamic azad university, isfahan, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
مهرداد نامداری | mehrdad namdari
lorestan university of medical sciences, khoramabad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی لرستان (Lorestan university of medical sciences)
مهدی حسن زاده | mehdi hassanzadeh
mashhad university of medical sciences, mashad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
علی اکبر tavasolli | ali akbar tavasolli
isfahan cardiovascular research center, isfahan cardiovascular research institute, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
صمد غفاری | samad ghaffari
tabriz university of medical sciences, tabriz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
ارسلان خالدی فر | arsalan khaledifar
shahrekord university of medical sciences, shahrekord, iran
فرشاد روغنی | farshad roghani
isfahan hypertension research center, isfahan cardiovascular research institute, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
محمد رضا خسروی | mohammad reza khosravi
shahrekord university of medical sciences, shahrekord, iran
شهروز صرامی | shahrooz sarami
department of pharmaceutics, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
جواد کجوری | javad kojouri
isfahan hypertension research center, isfahan cardiovascular research institute, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
فاطمه نوری | fatemeh nori
isfahan cardiovascular research center, isfahan cardiovascular research institute, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
الهام خسروی | elham khosravi
isfahan hypertension research center, isfahan cardiovascular research institute, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
مهناز جوزن | mahnaz jozan
isfahan hypertension research center, isfahan cardiovascular research institute, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
نضال صراف زادگان | nizal sarrafzadegan
isfahan cardiovascular research center, isfahan cardiovascular research institute, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
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