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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۳، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Coronary angiogenesis during experimental hypertension: is it reversible?
چکیده انگلیسی مقاله BACKGROUND: We investigated coronary angiogenesis and serum vascular endothelial growth factor (VEGF) and its soluble receptor-1 (sFlt-1) concentrations in two-kidney one-clip (2K1C) hypertensive rats before and after reversal of hypertension. METHODS: The animal groups were: (i) sham-clipped for 12 weeks; (ii) 2K1C for 12 weeks; (iii) sham-clipped for 12 weeks and unclipped for 12 weeks; and (iv) 2K1C for 12 weeks and unclipped for 12 weeks. Blood samples were taken before experiments and after clipping and unclipping; capillary density was also evaluated. RESULTS: Our results showed that blood pressure in hypertensive animals was higher than sham group (175 ± 10 vs. 110.3 ± 11.3 mmHg; p < 0.05). Unclipping significantly reduced blood pressure in hypertensive rats (p < 0.05). Serum VEGF and sFlt-1 levels in hypertensive group was significantly lower than sham group (VEGF: 74.36 ± 5.85 vs. 104.07 ± 7.75 pg/ml; sFlt-1: 426.67 ± 25.74 vs. 690.76 ± 41.14 pg/ml, respectively; p < 0.05). Unclipping in hypertensive animals increased serum VEGF and sFlt-1 concentrations (VEGF: 93.65 ± 8.61 vs. 74.36 ± 5.85 pg/ml; sFlt-1: 742.05 ± 79.23 vs. 426.67 ± 25.74 pg/ml, respectively; p < 0.05). In hypertensive animals, capillary density in the heart was higher than sham group, non-significantly (p > 0.05) and after unclipping, it reached to sham group level. CONCLUSIONS: It seems that changes in capillary density and serum VEGF and sFlt-1 concentrations in renovascular hypertension are reversible by removing the cause of hypertension and it shows the importance of early diagnosis and treatment of hypertension in clinical condition. KEYWORDS: Hypertension, Angiogenesis Inhibitor, Coronary Vessels, Vascular Endothelial Growth Factor Receptor-1.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله محمد زارعی | mohammad zarei
department of physiology, school of medicine, isfahan university of medical sciences, isfahan, iran. department of physiology, school of medicine, hamadan university of medical sciences, hamadan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مجید خزایی | majid khazaei
department of physiology, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد رضا شریفی | mohammad reza sharifi
department of physiology, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

علی اصغر پورشانظری | ali asghar pourshanazari
department of physiology, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/6025
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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