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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۳، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of soy phytoestrogen on metabolic and hormonal disturbance of women with polycystic ovary syndrome
چکیده انگلیسی مقاله BACKGROUND: Phytoestrogens are a group of plants derived compounds with weekly estrogen effect that appear to have protective effects on metabolic and hormonal abnormalities of women with polycystic ovary syndrome (PCOS). So the aim of this study was to investigate the effect of soy phytoestrogens on reproductive hormones and lipid profiles in PCOS women. METHODS: In this quasi-randomized trial, 146 subjects with PCOS were divided into two groups; the experimental group who received Genistein (Bergamon, Italy) 18 mg twice a day orally and the control group that received similar capsules with cellulose for 3 months. Hormonal features and lipid profiles were measured before and after 3 months of supplement therapy. RESULTS: After 3 months of supplement therapy there were no statistically significant differences in high density lipoprotein cholesterol (HDL) and follicle stimulating hormone (FSH) serum levels in Genistein and placebo group before and after treatment; however serum levels of luteinizing hormone (LH), triglyceride (TG), low density lipoprotein cholesterol (LDL), dehydroepiandrostrone sulfate (DHEAS) and testosterone were significantly decreased after 3 months therapy in Genistein group. CONCLUSIONS: Genistein consumption may prevent cardiovascular and metabolic disorders in PCOS patients by improving their reproductive hormonal and lipid profiles. KEYWORDS: Polycystic Ovary Syndrome, Genistein, Phytoestrogens , Cardiovascular Diseases.
کلیدواژه‌های انگلیسی مقاله Polycystic Ovary Syndrome, Genistein, phytoestrogens
نویسندگان مقاله بهناز خانی | behnaz khani
assistant professor, department of obstetrics and gynecology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فردوس محرابیان | ferdous mehrabian
associate professor, obstetrics and gynecology department, school of medicine, isfahan university of medical science, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

الهه خالصی | elaheh khalesi
department of obstetrics and gynecology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

آزاده اشراقی | azadeh eshraghi
school of pharmacy, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/6215
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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