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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۳، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Successful Prevention of Tunneled, Central Catheter Infection by Antibiotic Lock Therapy Using cefotaxime
چکیده انگلیسی مقاله BACKGROUND: Chronic hemodialysis patients frequently require vascular access through central venous catheters (CVCs). The most significant complication of these catheters is infection. This risk can be lowered by the use of an antibiotic-Heparin lock. This study focuses on hemodialysis patients using Tunneled-cuffed catheters (TCC), to assess the rate of catheter-related infections (CRI) in catheter-restricted filling with Cefotaxime and Heparin in end stage renal disease patients. METHODS: A double-blind randomized study was conducted to compare 5000 U/ml Heparin plus10 mg/ml cefotaxime (CE/HS) as catheter-lock solutions, with Heparin (5000 U/ml) alone. A total of 30 patients with end-stage renal disease and different etiologies, were enrolled for chronic hemodialysis with permanent catheters from December 2009 to March 2010. These patients were randomly assigned to two groups of 15 members. Blood samples were collected for culture, sensitivity and colony count, from the catheter lumen and the peripheral vein. CRI was considered as the end point. RESULTS: The rate of CRI was significantly lower in the cefotaxime group versus control group (p < 0.001). No exit site infection was occurred in both groups. Infection-free survival rates at 180 days were 100% for the CE/HS group, and 56% for the HS group. CONCLUSIONS: A ntibiotic lock therapy using Cefotaxime reduces the risk of CRI in hemodialysis patients. KEYWORDS: Catheter, Hemodialysis, Lock solution infection, Cefotaxime; Heparin.
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نویسندگان مقاله مژگان مرتضوی | mojgan mortazavi
isfahan kidney diseases research center, department of internal medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سمیرا alsaeidi | samira alsaeidi
isfahan kidney diseases research center, department of internal medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

روح اله سبحانی | roohollah sobhani
gonabad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گناباد (Gonabad university of medical sciences)

فرشته سلیمی | fereshte salimi
department of vascular surgery, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

عبدالامیر عطاپور | abdolamir atapour
isfahan kidney diseases research center, department of internal medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نیما شریف | nima sharif
school of medicine, ross university, usa


مجتبی اکبری | mojtaba akbari
isfahan kidney diseases research center, department of internal medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

بهرام پاکزاد | bahram pakzad
isfahan kidney diseases research center, department of internal medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

امیر حسین داورپناه جزی | amir hosein davarpanah jazi
medical education research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/6729
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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